Modified distribution of methylmercury by additional exposure to elemental mercury or mercuric chloride in mice fed methylmercuric chloride.
Modified distribution of methylmercury by additional exposure to elemental mercury or mercuric chloride in mice fed methylmercuric chloride.
复制标题
通过在喂食氯化甲基汞的小鼠中额外暴露于元素汞或氯化汞来改变甲基汞的分布。
DOI：
10.1248/bpb1978.3.80
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
T. Nobunaga
中科院分区：
文献类型：
--
作者：
R. Yamamoto;H. Satoh;T. Suzuki;T. Nobunaga
Male IVCS mice fed pellets containing 8 nmol methylmercuric chloride (MMC)/g feed for 32 days were additionally inhaled elemental mercury vapor (Hg0) or injected mercuric chloride (Hg2+). The modified distribution of accumulated organic mercury was observed 24 hr after exposure to inorganic mercurials. The body burden of organic mercury decreased significantly in MMC + Hg2+ treated mice and moderately (nor significant) in MMC + Hg0 treated mice when compared with MMC treated mice. In spite of the decreased body burden, the organic mercury levels in brain, kidneys and blood MMC + Hg0 treated mice, and in kidneys of MMC + Hg2+ treated mice were elevated. In bile, organic mercury concentration after Hg0 or Hg2+ exposure was reduced. The decrease of the blood cells-to-plasma ratio of organic mercury in mice after Hg0 exposure is in agreement with the data reported for workers exposed to mercury vapor.
