Highly Chemoselective Pd-C Catalytic Hydrodechlorination Leading to the Highly Efficient N-Debenzylation of Benzylamines
Highly Chemoselective Pd-C Catalytic Hydrodechlorination Leading to the Highly Efficient N-Debenzylation of Benzylamines
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DOI：
10.1021/jo9007282
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发表时间：
2009-08-07
影响因子：
3.6
通讯作者：
Hu, Yuefei
中科院分区：
文献类型：
--
作者：
Cheng, Chuanjie;Sun, Jianwei;Hu, Yuefei
在1，1，2-三氯乙烷存在下，建立了钯碳催化苄胺N-脱苄基反应的新方法。该方法在协同催化体系中进行，并以实际定量产率直接得到作为结晶胺盐酸盐的产物。
In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystal amine hydrochlorides in practically quantitative yields.