The Association Between Peer and own Aggression is Moderated by the BDNF Val-met Polymorphism.
The Association Between Peer and own Aggression is Moderated by the BDNF Val-met Polymorphism.
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DOI：
10.1111/jora.12050
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Barker ED
中科院分区：
文献类型：
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作者：
Kretschmer T;Vitaro F;Barker ED
同伴反社会行为对青少年自身行为有很强的预测作用，但并非所有青少年都同样容易受到同伴的影响，遗传因素可能会导致青少年的脆弱性。本研究使用的数据n = 3081青少年从雅芳纵向研究的父母和孩子（ALSPAC），研究是否BDNF，影响心理功能的多态性，缓和与侵略性的同龄人在10岁和自己的侵略在15岁之间的关联。一个显着的基因-环境相互作用被发现，其中那些在童年时期与攻击性同龄人有联系的人，如果他们携带BDNF met-met变体，与val-val携带者相比，他们在青春期表现出攻击性的风险增加。我们的研究结果强调了生物和社会因素对青少年发展的重要性。
Peer antisocial behavior robustly predicts adolescents’ own behavior but not all adolescents are equally vulnerable to their peers’ influence and genetic factors may confer vulnerability. This study used data of n = 3081 adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) to examine whether BDNF, a polymorphism that affects psychological functioning, moderates the association between affiliation with aggressive peers at age 10 and own aggression at age 15. A significant gene-environment interaction was found, where those who affiliated with aggressive peers in childhood showed increased risk for being aggressive in adolescence if they carried the BDNF met-met variant compared to val-val carriers. Our findings underline the importance of both biological and social factors for adolescent development.