Aggravation of gingival inflammatory symptoms during pregnancy associated with the concentration of plasminogen activator inhibitor type 2 (PAI-2) in gingival fluid.
Aggravation of gingival inflammatory symptoms during pregnancy associated with the concentration of plasminogen activator inhibitor type 2 (PAI-2) in gingival fluid.
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妊娠期间牙龈炎症症状的加重与牙龈液中纤溶酶原激活剂抑制剂 2 型 (PAI-2) 的浓度有关。
DOI：
10.1111/j.1600-0765.1996.tb00493.x
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发表时间：
1996
影响因子：
3.5
通讯作者：
B. Åstedt
中科院分区：
文献类型：
--
作者：
B. Kinnby;L. Matsson;B. Åstedt
怀孕期间牙龈炎症症状会加重。体外研究表明，激素对 2 型纤溶酶原激活剂抑制剂 (PAI-2) 的影响以及纤溶系统平衡的紊乱可能有助于解释妊娠期牙龈炎。对 14 名怀孕和怀孕后妇女的龈沟液 (GCF) 进行了采样。通过 Løe & Silness (GI) 牙龈指数评估牙龈状况，通过 Silness & Løe (PI) 菌斑指数评估菌斑量。计算牙龈炎部位与菌斑部位的比率（G/P 比）。采用 ELISA 测定 GCF 中组织纤溶酶原激活剂 (t-PA)、尿激酶型纤溶酶原激活剂 (u-PA)、1 型纤溶酶原激活剂抑制剂 (PAI-1) 和 PAI-2 的抗原水平，并采用放射免疫测定法测定血清中 17β-雌二醇和孕酮的抗原水平。对于每个个体，计算怀孕期间和怀孕后之间激素水平以及 PA 和 PAI 的差异 (delta)。根据妊娠期和妊娠后 G/P 比的差异，将其分为高反应组和低反应组。对于整个组来说，怀孕期间的平均 G/P 比为 2.0，怀孕后的平均 G/P 比为 1.2 (p = 0.064)。注意到 δ 黄体酮和 δ PAI-2 之间存在统计学上显着的相关性：δ 黄体酮越高，δ PAI-2 越低。没有发现激素水平和纤溶系统成分之间存在其他显着相关性。对于整个女性组来说，怀孕期间 PAI-2、PAI-1 和 t-PA 的浓度显着高于怀孕后。然而，高反应组的个体在怀孕期间表现出较低或不变的 PAI-2 产量，而低反应组的个体则表现出大大增加的产量。炎症反应较高的女性在怀孕期间 PAI-2 产生量较低，抑制能力较低，这表明纤溶系统的成分可能参与妊娠牙龈炎的发展，并暗示 PAI-2 作为组织蛋白水解的重要抑制剂。目前的发现有助于解释妊娠牙龈炎。
Gingival inflammatory symptoms are aggravated during pregnancy. In vitro studies suggest a hormonal influence on the plasminogen activator inhibitor type 2 (PAI-2), and a disturbed balance of the fibrinolytic system could help to explain pregnancy gingivitis. Gingival crevicular fluid (GCF) was sampled in 14 women in pregnant and post-pregnant states. The gingival condition was assessed by the gingival index of Løe & Silness (GI) and the amount of bacterial plaque by the plaque index of Silness & Løe (PI). The ratio of sites with gingivitis to sites with bacterial plaque was calculated (G/P-ratio). Antigen levels of tissue plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA), plasminogen activator inhibitors type 1 (PAI-1) and PAI-2 in GCF were determined with ELISAs and 17 beta-oestradiol and progesterone in serum with radioimmunoassays. For each individual the differences (delta) in hormone levels and PAs and PAIs between pregnancy and post-pregnancy were calculated. Based on differences in G/P-ratio between pregnancy and post-pregnancy, subgrouping was done into a high-reacting and a low-reacting group. For the total group, the mean G/P-ratio was 2.0 during and 1.2 after pregnancy (p = 0.064). A statistically significant correlation between delta progesterone and delta PAI-2 was noted: the higher delta progesterone, the lower delta PAI-2. No other significant correlations between hormone levels and components of the fibrinolytic system were found. For the total group of women, the concentrations of PAI-2, PAI-1 and t-PA were significantly higher during than after pregnancy. The individuals in the high-reacting group, however, showed a lower or unchanged production of PAI-2 during pregnancy, while those in the low-reacting group showed a greatly increased production. The lower inhibitory capacity in terms of a low production of PAI-2 during pregnancy in women with a higher inflammatory reaction indicates that the components of the fibrinolytic system may be involved in the development of pregnancy gingivitis and implies that PAI-2 serves as an inhibitor of importance for tissue proteolysis. The present finding contributes to the explanation of pregnancy gingivitis.
表达重组纤溶酶原激活剂抑制剂2对HT1080肉瘤细胞侵袭的抑制作用。
影响因子：
11.2
作者：
Laug,WE;Cao,XR;Yu,YB;Shimada,H;Kruithof,EK
通讯作者：
Kruithof,EK
2 型纤溶酶原激活剂抑制剂的释放增加伴随着人类单核细胞组织因子对脂多糖的反应。
影响因子：
20.3
作者：
Schwartz,BS;Monroe,MC;Levin,EG
通讯作者：
Levin,EG
脂多糖诱导的人单核细胞尿激酶产生和活性的调节。
DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Manchanda,N;Schwartz,BS
通讯作者：
Schwartz,BS