Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex.
Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex.
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Ezh2通过调节大脑皮层Reelin表达参与放射状神经元迁移
DOI：
10.1038/srep15484
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发表时间：
2015-10-26
影响因子：
4.6
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Zhao L;Li J;Ma Y;Wang J;Pan W;Gao K;Zhang Z;Lu T;Ruan Y;Yue W;Zhao S;Wang L;Zhang D
锥体神经元的径向迁移是大脑皮层发育过程中的重要事件。神经元经历一系列形态和方向的转变，以达到其最终的层状位置。在这里，我们报告，组蛋白甲基转移酶增强子的zest同源物2（EZH2）参与调节皮质径向迁移。我们发现，Ezh2敲低导致神经元取向紊乱，从而导致径向迁移受损。进一步的结果表明，这种迁移缺陷可能是由于迁移神经元中Reelin转录的去抑制。我们的研究提供了证据表明，Ezh2的Reelin的表观遗传调节维持适当的Reelin表达模式，以实现迁移神经元的正确定向。
Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the regulation of cortical radial migration. We show that Ezh2 knockdown leads to disturbed neuronal orientation, which results in the impairment of radial migration. Further results reveal that this migration deficiency may be due to the derepression ofReelintranscription in the migrating neurons. Our study provides evidence that epigenetic regulation of Reelin by Ezh2 maintains appropriate Reelin expression pattern to fulfill proper orientation of migrating neurons.