Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function
Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function
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DOI：
10.1371/journal.pone.0034851
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发表时间：
2012-04-16
期刊：
影响因子：
3.7
通讯作者：
Heazell, Alexander E. P.
中科院分区：
文献类型：
--
作者：
Warrander, Lynne K.;Batra, Gauri;Heazell, Alexander E. P.
背景：母亲对胎动减少（RFM）的感知与死产和胎儿生长受限（FGR）风险增加相关。 DFM 被认为代表由于胎盘功能不全导致氧气和营养转移不足而导致胎儿为了保存能量而进行的补偿。迄今为止，尚未对 DFM 病例中的胎盘结构进行研究。目的：确定母亲对胎动减少 (RFM) 的感知是否与胎盘结构和功能异常相关。设计：如果分娩发生在 1 周内，则在妊娠 28 周后从患有 RFM 的妇女中收集胎盘。运动正常的女性作为对照组。对胎盘进行称重并拍照。通过免疫组织化学染色和图像分析评估显微结构。测量系统A氨基酸转运蛋白活性作为胎盘功能的标志。所有 RFM 妊娠（无论结果如何）的胎盘都有更大面积的梗塞迹象（3.5% vs. 0.6%；p
Background: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM.Objective: To determine whether maternal perception of reduced fetal movements (RFM) is associated with abnormalities in placental structure and function.Design: Placentas were collected from women with RFM after 28 weeks gestation if delivery occurred within 1 week. Women with normal movements served as a control group. Placentas were weighed and photographs taken. Microscopic structure was evaluated by immunohistochemical staining and image analysis. System A amino acid transporter activity was measured as a marker of placental function. Placentas from all pregnancies with RFM (irrespective of outcome) had greater area with signs of infarction (3.5% vs. 0.6%; p