Outbreak of Multiresistant OXA-24-and OXA-51-Producing Acinetobacter baumannii in an Internal Medicine Ward
Outbreak of Multiresistant OXA-24-and OXA-51-Producing Acinetobacter baumannii in an Internal Medicine Ward
复制标题
DOI：
10.7883/yoken.66.323
复制
发表时间：
2013-07-01
影响因子：
2.2
通讯作者：
Bisquert, Julia
中科院分区：
文献类型：
--
作者：
Tena, Daniel;Mariela Martinez, Nora;Bisquert, Julia
在这里，我们描述了临床，微生物学，流行病学和分子特征的多重耐药鲍曼不动杆菌（MRAB）的爆发，涉及5例患者入住我院内科病房。在6周内，从5例患者中回收了5株MRAB分离株，包括1例致死性脑膜炎，3例皮肤和软组织感染，1例呼吸道定植。在病房环境监测期间获得的一份样品为A。鲍氏阳性根据脉冲场凝胶电泳分型结果，从所有患者和环境样品中分离的菌株均为单克隆，经多位点序列分型鉴定为ST 79。在所有分离株中均检出bla（OXA-24）和bla（OXA-51）碳青霉烯酶。死亡4例，但只有脑膜炎患者的死亡可能与A。鲍曼不动杆菌感染感染源可能是医护人员的手，因为爆发菌株是从血清容器表面分离出来的。本研究的结果揭示了所有医护人员严格遵守控制措施的重要性，因为不遵守的后果可能非常严重。
Here we describe the clinical, microbiological, epidemiological, and molecular characterization of an outbreak of multidrug-resistant Acinetobacter baumannii (MRAB) involving 5 patients admitted to the internal medicine ward of our hospital. Over a 6-week period, 5 MRAB isolates were recovered from 5 patients, including 1 with fatal meningitis, 3 with skin and soft tissue infections, and 1 with respiratory colonization. One sample obtained during environmental monitoring in the ward was A. baumannii-positive. According to the pulsed-field gel electrophoresis typing results, the strains isolated from all patients and the environmental sample belonged to a single clone, identified as ST79 by multilocus sequence typing. The bla(OXA-24) and bla(OXA-51) carbapenemases were detected in all isolates. Four patients died, but only the death of the meningitis patient was probably related to the A. baumannii infection. The infection source was probably the hands of the healthcare workers because the outbreak strain was isolated from the surface of a serum container. The results of the present study revealed the importance of strict adherence to control measures by all healthcare workers because the consequences of noncompliance can be very serious.