Diversification of cardiomyogenic cell lineages during early heart development.
Diversification of cardiomyogenic cell lineages during early heart development.
复制标题
早期心脏发育过程中心肌细胞谱系的多样化。
DOI：
10.1161/01.res.77.2.216
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发表时间：
1995
影响因子：
20.1
通讯作者：
Bader,D
中科院分区：
文献类型：
--
作者：
Yutzey,KE;Bader,D
脊椎动物的心脏是由有限数量的良好表征的细胞类型，因此是一个很好的系统，在其中研究谱系决定事件和器官发生。心房和心室肌源性谱系的多样化在完全形成的心脏的形态学、生理学和分子组成中是明显的，并且对于心脏的循环和内分泌功能是必不可少的。我们实验室和其他人最近的工作已经检查了心房和心室肌细胞谱系从发育的最早阶段的起源。这些研究已经解决了这些谱系在早期脊椎动物胚胎中出现的位置，多样化的细胞谱系在原始心脏中首次出现的时间，以及导致这些谱系分离的机制。关于肌细胞谱系多样化的许多信息是通过对早期鸡胚胎的研究获得的，因为其可获得性和胚胎学操作的潜力。在小鼠、青蛙和斑马鱼中的额外研究大大提高了我们对早期脊椎动物心脏发生的认识。总之，这些研究表明，心房和心室肌源性谱系的分离发生在心室形成之前，并且这些谱系的确定主要基于非常早期胚胎中心脏祖细胞的前后极性。在本通讯中，我们回顾了起源的谱系和分子事件参与产生心房和心室肌细胞群体。
The vertebrate heart is composed of a limited number of well-characterized cell types and therefore is an excellent system in which to study lineage-determination events and organogenesis. The diversification of atrial and ventricular myogenic lineages is evident in the morphology, physiology, and molecular composition of the fully formed heart and is essential to the circulatory and endocrine functions of the heart. Recent work from our laboratory and others has examined the origins of the atrial and ventricular myocyte cell lineages from the earliest stages of development. These studies have addressed where these lineages arise in the early vertebrate embryo, when diversified cell lineages are first evident in the primitive heart, and what mechanisms result in the separation of these lineages. Much of the information regarding myocyte lineage diversification has been obtained by study of the early chicken embryo because of its accessibility and potential for embryological manipulation. Additional studies in the mouse, frog, and zebra fish have significantly advanced our knowledge of early vertebrate cardiogenesis. Taken together, these studies demonstrated that the separation of atrial and ventricular myogenic lineages occurs before heart chamber formation and that the determination of these lineages is primarily based on the anteroposterior polarity of the heart progenitors in the very early embryo. In the present communication, we review the origins of the lineages and molecular events involved in generating atrial and ventricular myocyte populations.