VARIATIONS IN THE PERMEABILITY OF THE RED BLOOD CELLS IN MAN, WITH PARTICULAR REFERENCE TO THE CONDITIONS OBTAINING IN PERNICIOUS ANEMIA.
VARIATIONS IN THE PERMEABILITY OF THE RED BLOOD CELLS IN MAN, WITH PARTICULAR REFERENCE TO THE CONDITIONS OBTAINING IN PERNICIOUS ANEMIA.
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人类红细胞通透性的变化，特别是恶性贫血的情况。
DOI：
10.1172/jci100857
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发表时间：
1937
期刊：
影响因子：
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通讯作者：
S. L. Orskov
中科院分区：
文献类型：
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作者：
O. Bang;S. L. Orskov
众所周知，人是血细胞对葡萄糖具有渗透性的少数物种之一。人血细胞对葡萄糖的渗透率一直是许多研究的主题，这些研究试图定义这种现象的重要因素。Ege（1）是第一个研究葡萄糖浓度重要性的人。当葡萄糖浓度较低时，细胞外液中的葡萄糖和血细胞的水相之间迅速达到平衡;当葡萄糖浓度较高时，血细胞逐渐肿胀，向内扩散的速度慢得多（然而，一个促成因素可能是钾从血细胞同时向外流动）。Bjering（2）对这些条件进行了更彻底的研究，他同样发现，当葡萄糖浓度升高时，扩散速率变慢。他进一步指出，随着更多的葡萄糖进入血细胞，葡萄糖的扩散速率逐渐降低，其程度大于菲克定律1的预期。“有很多证据表明，这是一个在葡萄糖分子存在下血细胞膜孔隙收紧的问题，因为当使用胶体膜时观察到类似的扩散速率降低。Bjering还表明，葡萄糖的内向流动可以通过向sus-sugar中加入氰化汞而完全停止。
Man, as is well known, is one of the few species whose blood cells are permeable to glucose. The permeability rate of human blood cells for glucose has been the subject of many investigations attempting to define the significant factors of this phenomenon. Ege (1) was the first to investigate the importance of the concentration of the glucose. With a low glucose concentration there rapidly occurred a balance between'the glucose in the extracellular fluid and the watery phase of the blood cells; with a higher degree of concentration, the blood cells gradually became swollen, with a much slower inward diffusion rate (a contributing factor here, however, was a probable simultaneous outward flow of potassium from the blood cells). These conditions were more thoroughly examined by Bjering (2) who likewise found the rate of diffusion slower when the concentration of glucose was raised. He noted further that the diffusion rate for glucose gradually diminished to a degree greater than might be expected from Fick's law 1 as more glucose entered the blood cells. 'There is much to suggest that it is a question of a tightening of the pores of the blood cell membranes in the presence of glucose molecules, as a similar lowering of the diffusion rate has been observed when collodium membranes are employed. Bjering showed too that the inward flow of the glucose could be brought to a complete standstill by the addition of cyanide of mercury to the sus-