Suppression of natural killer cell activity by Friend murine leukemia virus.
Suppression of natural killer cell activity by Friend murine leukemia virus.
复制标题
Friend 鼠白血病病毒对自然杀伤细胞活性的抑制。
DOI：
10.1093/jnci/72.6.1349
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
H. Friedman
中科院分区：
文献类型：
--
作者：
D. Moody;S. Specter;M. Bendinelli;H. Friedman
BALB/c mice infected with Friend murine leukemia virus (F-MuLV) evinced a decreased natural killer (NK) cell activity to susceptible target cells. This suppression increased as the interval between infection and assay was lengthened. The decrease in NK activity due to F-MuLV infection was partially reversible when spleen cells were pretreated with interferon before the cytolytic assay. The ability of F-MuLV-infected splenocytes to bind to target cells was unaltered, indicating that the defect was in the lytic phase of NK cytolysis. When mixed with uninfected spleen cells, F-MuLV-infected splenocytes suppressed their NK cell activity. This suppression was associated with a nylon wool-adherent cell population in the F-MuLV-infected spleens.
