Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum
Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum
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徐长卿根中抑制食欲的孕烷苷
DOI：
10.1016/j.phytochem.2013.03.010
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发表时间：
2013-09-01
期刊：
影响因子：
3.8
通讯作者：
Zhao, Weimin
中科院分区：
文献类型：
--
作者：
Liu, Shuangzhu;Chen, Zhenhua;Zhao, Weimin
为了寻找含有P57（一种具有潜在食欲抑制作用的孕苷）的虎耳草的植物替代品，研究了金秋草的根。结果，15个孕烷苷被分离出来，其中9个以前从未报道过。它们的结构在广泛的光谱分析和化学方法的基础上得到了阐明。用孕苷含量最高的wilfoside K1N对大鼠进行体内实验，观察其抑制食欲和减轻体重的作用。(C) 2013 Elsevier Ltd.版权所有。
In the search for plant alternatives to Hoodia gordonii containing P57, a pregnane glycoside with potential appetite suppressant effect, the roots of Cynanchum auriculatum were investigated. As a result, 15 pregnane glycosides including nine never previously reported were isolated. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. Appetite suppressant effect and body weight loss were observed when tested with the most abundant pregnane glycoside, wilfoside K1N, in an in vivo test with rats. (C) 2013 Elsevier Ltd. All rights reserved.