Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors: J-HOPE study.
Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors: J-HOPE study.
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DOI：
10.1186/1471-244x-12-33
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发表时间：
2012-04-20
期刊：
影响因子：
4.4
通讯作者：
Shimbo T
中科院分区：
文献类型：
--
作者：
Miyaki K;Song Y;Htun NC;Tsutsumi A;Hashimoto H;Kawakami N;Takahashi M;Shimazu A;Inoue A;Kurioka S;Shimbo T
近年来，影响心理健康的社会经济状况(SES)和工作压力指数受到越来越多的关注。叶酸的摄入被认为与抑郁症有负相关。然而，很少有研究将SES和工作压力因素与证据联系起来。目前的研究是日本健康、职业和心理社会因素相关公平研究(J-HOPE研究)的一部分，该研究侧重于社会分层与健康的关联，我们的目标是澄清日本普通工人叶酸摄入量与抑郁症状之间的关联。受试者是一家日本全国性公司的2266名工人。采用自填式问卷测评社会支持量表和工作压力因素。叶酸摄入量通过一份有效的、简短的、自我管理的饮食历史问卷来估计。抑郁症状采用Kessler‘s K6问卷测评。有抑郁症状者定义为K6≧9(K6评分0~24分)。用多元Logistic回归和线性回归模型评价叶酸与抑郁症状的关系。在有抑郁症状的受试者中，多项社会支持因素(管理职位比例、连续工作年限和家庭年收入)和叶酸摄入量显著降低(社会支持因素：P <； 0.001；叶酸摄入量：P = 0.001)。在调整了年龄、性别、工作压力评分(工作压力、工作场所支持)和社会支持因素后，K6评分和叶酸摄入量之间存在负的、独立的线性关联(p = 0.010)。多因素Logistic回归分析显示，叶酸摄入对抑郁症状发生率的影响为(OR[95%CI]：0.813[0.664~0.994]；P=0.044)。我们的横断面研究表明，能量调整的叶酸摄入量与日本工人的抑郁评分和抑郁症状的患病率之间存在反向的、独立的关系，同时考虑了社会经济地位和工作压力因素。
Recently socioeconomic status (SES) and job stress index received more attention to affect mental health. Folate intake has been implicated to have negative association with depression. However, few studies were published for the evidence association together with the consideration of SES and job stress factors. The current study is a part of the Japanese study of Health, Occupation and Psychosocial factors related Equity (J-HOPE study) that focused on the association of social stratification and health and our objective was to clarify the association between folate intake and depressive symptoms in Japanese general workers. Subjects were 2266 workers in a Japanese nationwide company. SES and job stress factors were assessed by self-administered questionnaire. Folate intake was estimated by a validated, brief, self-administered diet history questionnaire. Depressive symptoms were measured by Kessler’s K6 questionnaire. “Individuals with depressive symptoms” was defined as K6≧9 (in K6 score of 0–24 scoring system). Multiple logistic regression and linear regression model were used to evaluate the association between folate and depressive symptoms. Several SES factors (proportion of management positions, years of continuous employment, and annual household income) and folate intake were found to be significantly lower in the subjects with depressive symptom (SES factors: p < 0.001; folate intake: P = 0.001). There was an inverse, independent linear association between K6 score and folate intake after adjusting for age, sex, job stress scores (job strains, worksite supports), and SES factors (p = 0.010). The impact of folate intake on the prevalence of depressive symptom by a multiple logistic model was (ORs[95% CI]: 0.813 [0.664-0.994]; P =0.044). Our cross-sectional study suggested an inverse, independent relation of energy-adjusted folate intake with depression score and prevalence of depressive symptoms in Japanese workers, together with the consideration of SES and job stress factors.