Current status of treatment completion and fatality among tuberculosis patients in Spain.
Current status of treatment completion and fatality among tuberculosis patients in Spain.
复制标题
西班牙结核病患者治疗完成情况和死亡率的现状。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
H. Galdós
中科院分区：
文献类型：
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作者：
J. Caylà;J. Caminero;R. Rey;N. Lara;X. Vallès;H. Galdós
目标
确定结核病患者的治疗完成率，并分析与治疗失误和死亡率相关的因素。
方法
对1999年6月1日至2000年5月31日期间在SEPAR结核病和呼吸道感染小组成员工作的地区开始治疗的患者进行的前瞻性队列研究。采用Logistic回归分析与治疗失误和病死率相关的因素，计算优势比(OR)及其95%可信区间(95%CI)。
结果
这项研究涉及来自76家不同医院的142名医生，他们提供了1515例病例的信息。82%的患者正确完成治疗，14%的患者违约，5%的患者死亡，0.5%的患者失败，8.7%的患者因转院或其他原因中断治疗。与违约相关的变量有静脉吸毒(OR 6.00，95%CI 2.59~13.89)和移民(OR 8.57，95%CI 3.78~19.45)，性别、年龄、无家可归、监禁、直接观察治疗(DOT)或住院与违约无关。可预测死亡的变量有酗酒(OR 6.38，95%CI 2.09~19.48)、人类免疫缺陷病毒感染(OR 7.08，95%CI 2.08~29.15)和年龄年限(OR 10，95%CI 2.9~34.07)，而性别、静脉吸毒、无家可归、DOT和住院时间不能预测死亡。
结论
在工业化国家，静脉吸毒患者和移民应该成为DOT的目标人群，而为了降低死亡率，需要对酗酒、感染艾滋病毒或年事已高的患者进行更严格的监测。
OBJECTIVES
To determine treatment completion among patients with tuberculosis (TB), and to analyse factors associated with treatment default and fatality.
METHODS
A prospective cohort study of patients who began treatment between 1 June 1999 and 31 May 2000 in areas where members of the SEPAR Tuberculosis and Respiratory Infections Group work. Factors associated with treatment default and fatality were studied using logistic regression, calculating odds ratios (OR) and their 95% confidence intervals (95%CI).
RESULTS
The study involved 142 physicians from 76 different hospitals who provided information on 1515 cases. Eighty-two per cent of the patients completed treatment correctly, 14% defaulted, 5% died, 0.5% failed, and 8.7% interrupted treatment due to transfer or other reasons. The variables associated with default were intravenous drug use (IVDU) (OR 6.00, 95%CI 2.59-13.89) and immigration (OR 8.57, 95%CI 3.78-19.45); sex, age, homelessness, incarceration, directly observed treatment (DOT) or hospitalisation were not associated with default. Variables found to be predictive of fatality were alcoholism (OR 6.38, 95%CI 2.09-19.48), human immunodeficiency virus (HIV) infection (OR 7.08, 95%CI 2.08-29.15) and age >64 years (OR 10, 95%CI 2.9-34.07), whereas sex, IVDU, homelessness, DOT and hospitalisation were not.
CONCLUSIONS
In industrialised countries, IVDU patients and immigrants should be targeted for DOT, while to reduce fatality rates stricter monitoring is required for patients who are alcoholic, HIV-infected, or aged >64 years.
一种在艾滋病毒流行地区直接观察治疗结核病的新方法。
影响因子：
12.7
作者：
Desvarieux,M;Hyppolite,PR;JohnsonJr,WD;Pape,JW
通讯作者：
Pape,JW