Glycoprotein Ib-IX-V
Glycoprotein Ib-IX-V
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DOI：
10.1016/s1357-2725(02)00280-7
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发表时间：
2003-08-01
影响因子：
4
通讯作者：
Berndt, MC
中科院分区：
文献类型：
--
作者：
Andrews, RK;Gardiner, EE;Berndt, MC
糖蛋白（GP）Ib-IX-V是富含亮氨酸重复序列家族的一种显著的血小板粘附受体。它已经发展到履行其在流动血液中的高剪切应力下引发血小板聚集（血栓形成）的主要功能。除了结合内皮下基质或血浆中的血管性血友病因子（vWF）以触发血小板聚集之外，GPIb-IX-V还结合中性粒细胞上的反受体α M β 2（Mac-1）或活化的血小板或内皮细胞上的P-选择素。GPIb-IX-V配体还包括α-凝血酶、凝血因子XI/XIIa和高分子量激肽原。因此，涉及GPIb-IX-V的相互作用是血栓形成和炎症的血管过程的中心，并且受体作为潜在的治疗靶点受到严格的审查。(C)2003爱思唯尔科技有限公司版权所有。
Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, alphaMbeta2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells. GPIb-IX-V ligands also include alpha-thrombin, clotting factors XI/XIIa, and high-molecular-weight kininogen. Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target. (C) 2003 Elsevier Science Ltd. All rights reserved.