Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans
Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans
复制标题
DOI：
10.1523/jneurosci.1982-05.2005
复制
发表时间：
2005-10-05
影响因子：
5.3
通讯作者：
Stern, CE
中科院分区：
文献类型：
--
作者：
Schon, K;Atri, A;Stern, CE
最近的计算建模和切片生理学研究表明，长期编码可能依赖于海马旁神经元短暂记忆延迟期间的持续尖峰，并且这种持续尖峰活动受到乙酰胆碱对毒蕈碱受体的影响的调节。我们最近的功能性磁共振成像（fMRI）研究已经表明，在健康年轻个体中延迟匹配样本表现期间持续的海马旁延迟期活动预测了20分钟后识别记忆评估中视觉刺激的后续记忆（Schon等人，2004年）。目前的研究结合了这一功能磁共振成像范例与药理学操作，以测试是否这种长期的编码相关的延迟活动减少在受试者接受毒蕈碱胆碱能拮抗剂东莨菪碱前功能磁共振成像扫描。随后的记忆预测持续活动期间短暂的记忆延迟双边在嗅周/内嗅皮质，在右后海马旁和中梭状回，在海马体中的健康年轻人没有东莨菪碱的挑战。这种活性在接受东莨菪碱的受试者中降低。结果与计算模型数据和行为药理学研究一致，表明如果胆碱能受体被东莨菪碱阻断，长期编码相关的活性可能会降低。
Recent computational modeling and slice physiology studies have suggested that long- term encoding may depend on sustained spiking during brief memory delays in parahippocampal neurons, and that this persistent spiking activity is modulated by effects of acetylcholine at muscarinic receptors. Our recent functional magnetic resonance imaging (fMRI) study has shown that sustained parahippocampal delay period activity during delayed match-to-sample performance in healthy young individuals predicted subsequent memory of visual stimuli on a recognition memory assessment 20 min later (Schon et al., 2004). The current study combined this fMRI paradigm with a pharmacological manipulation to test whether this long-term encoding-related delay activity is reduced in subjects who receive the muscarinic cholinergic antagonist scopolamine before fMRI scanning. Subsequent memory was predicted by sustained activity during brief memory delays bilaterally in the perirhinal/entorhinal cortex, in the right posterior parahippocampal and mid-fusiform gyri, and in the hippocampal body in healthy young individuals without a scopolamine challenge. This activity was reduced in subjects receiving scopolamine. The results are consistent with computational modeling data and behavioral pharmacological studies, suggesting that long-term encoding-related activity may be reduced if cholinergic receptors are blocked by scopolamine.