Maternal Preeclampsia Predicts the Development of Bronchopulmonary Dysplasia
Maternal Preeclampsia Predicts the Development of Bronchopulmonary Dysplasia
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DOI：
10.1016/j.jpeds.2009.10.018
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发表时间：
2010-04-01
影响因子：
5.1
通讯作者：
McElrath, Thomas F.
中科院分区：
文献类型：
--
作者：
Hansen, Anne R.;Barnes, Carmen M.;McElrath, Thomas F.
目的验证先兆子痫与支气管肺发育不良（BPD）风险增加相关的假设。研究设计对107名妊娠23至32周出生的婴儿进行前瞻性队列研究，收集孕产妇、新生儿和胎盘数据。结果在研究的107名婴儿中，27名（25%）患有BPD。先兆子痫与BPD之间关系的双变量比值比（OR）为2.96（95%置信区间[CI] = 1.17至7.51; P = 0.01）。当控制胎龄、出生体重z评分、绒毛膜炎和其他临床混杂因素时，发生BPD的OR为18.7（95%CI = 2.44至144.76）。包括先兆子痫的发生，临床绒毛膜炎，男性，和母亲的烟草使用，除了胎龄和出生体重Z-评分占54%的变异的几率发展BPD.Conclusions BPD是增加暴露于先兆子痫的婴儿。这可能意味着预防BPD与促血管生成剂，如血管内皮生长因子。（J Pediatr 2010; 156：532-6）。
Objective To test the hypothesis that exposure to preeclampsia is associated with an increased risk of bronchopulmonary dysplasia (BPD).Study design A prospective cohort study of 107 babies born between 23 and 32 weeks gestation, collecting maternal, neonatal, and placental data.Results Of the 107 infants studied, 27 (25%) developed BPD. The bivariate odds ratio (OR) for the relationship between pre-eclampsia and BPD was 2.96 (95% confidence interval [CI] = 1.17 to 7.51; P = .01). When controlling for gestational age, birth weight z-score, chorioamnionitis, and other clinical confounders, the OR of developing BPD was 18.7 (95% CI = 2.44 to 144.76). Including the occurrence of preeclampsia, clinical chorioamnionitis, male sex, and maternal tobacco use in addition to gestational age and birth weight z-score accounted for 54% of the variability of the odds of developing BPD.Conclusions BPD is increased for infants exposed to preeclampsia. This has possible implications for the prevention of BPD with proangiogenic agents, such as vascular endothelial growth factor. (J Pediatr 2010; 156: 532-6).