Coiled-Coil Domain
Coiled-Coil Domain
复制标题
卷曲线圈域
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
M. Rasmussen
中科院分区：
文献类型：
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作者：
M. Rasmussen
一种结构域，通过非常有效地埋藏疏水侧链来稳定蛋白质中的α螺旋，使极性水分子无法接近它们。因此，螺旋非常稳定。事实上，许多必须承受相当大压力的结构蛋白（角蛋白、原肌球蛋白、层粘连蛋白）都有一个盘绕结构域。两个基本特征是共同的：(1)总体二级结构是α螺旋结构，(2)疏水残基排列在螺旋的一侧。疏水残基在盘绕结构域的典型定位通常可以从蛋白质的一级结构中识别出来。螺旋可以平行也可以反平行。当螺旋属于不同的多肽时，前者是常见的，后者在由单个多肽链组成的线圈中普遍存在。线圈中的螺旋数通常在2到4之间变化。Qeios·定义，2020年2月2日
A domain that stabilizes alpha helices in proteins through a very efficient burial of hydrophobic side chains so that polar water molecules do not access them. As a result, the helices are quite stable. In fact, many structural proteins (keratins, tropomyosin, laminin) that have to bear considerable stress have a coiled-coil domain. T wo basic essential features are common: (1) the overall secondary structure is alpha helical, (2) the hydrophobic residues are arranged on one side of the helices. T he typical positioning of the hydrophobic residues in the coiled-coil domain can be often recognized from primary structure of the protein. T he helices can be parallel or antiparallel. T he former is common when the helices belong to different polypeptides and the latter prevails in coiled coils made up from a single polypeptide chain. T he number of helices in the coil varies usually between 2 and 4. Qeios · Definition, February 2, 2020