Cerebrospinal fluid vasopressin levels -: Correlates with aggression and serotonin function in personality-disordered subjects
Cerebrospinal fluid vasopressin levels -: Correlates with aggression and serotonin function in personality-disordered subjects
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DOI：
10.1001/archpsyc.55.8.708
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发表时间：
1998-08-01
影响因子：
--
通讯作者：
Ferris, CF
中科院分区：
文献类型：
--
作者：
Coccaro, EF;Kavoussi, RJ;Ferris, CF
背景：动物研究表明，中枢加压素在攻击行为中起易化作用。为了研究人类的这种可能性，在人格障碍受试者中研究了脑脊液（CSF）精氨酸加压素（AVP）与攻击指数和中枢5-羟色胺系统功能之间的关系。我们用脑脊液（AVP）、脑脊液5-羟基吲哚乙酸和催乳素对d-芬氟拉明激发的反应（PRL[d-FEN]）作为加压素和肾上腺素能系统功能的中心指标，分别在26名符合DSM-TV人格障碍标准的受试者中进行。攻击和冲动的措施，包括生活史的攻击评估和Barratt冲动Scales.Results：CSF AVP水平与生活史的一般攻击和攻击对人和与PRL[d-FEN]反应呈负相关（但不与CSF 5-羟基吲哚乙酸），这反过来又与这2个措施的生活史的攻击。CSF AVP和攻击性生活史之间的正相关关系仍然存在，即使在这些subjects. Conclusions的PRL[d-FEN]反应相关的变量时，中央AVP可能发挥作用，而5-羟色胺发挥作用，在人格障碍的个体的增强，攻击性行为。除了中枢AVP和5-羟色胺相互作用影响人类攻击性的可能性之外，中枢AVP还可能通过人格障碍受试者中独立于中枢5-羟色胺的机制影响人类攻击性行为。
Background: Animal studies suggest that central vasopressin plays a facilitatory role in aggressive behavior. To examine this possibility in humans, the relationship between cerebrospinal fluid (CSF) arginine vasopressin (AVP) and indices of aggression and central serotonin system function was examined in personality-disordered subjects.Methods: We used CSF (AVP), CSF 5-hydroxyindoleacetic acid, and the prolactin response to d-fenfluramine challenge (PRL[d-FEN]) as central indices of vasopressin and serotonergic system function, respectively, in 26 subjects who met the DSM-TV criteria for personality disorder. Measures of aggression and impulsivity included the Life History of Aggression assessment and the Barratt Impulsiveness Scales.Results: The CSF AVP level was correlated directly with life history of general aggression and aggression against persons and inversely with PRL[d-FEN] responses (but not with CSF 5-hydroxyindoleacetic acid), which in turn was correlated inversely with these 2 measures of Life history of aggression. The positive relationship between CSF AVP and life history of aggression remained even when the variance associated with PRL[d-FEN] responses in these subjects was accounted for.Conclusion: Central AVP may play a role in enhancing, while serotonin plays a role in inhibiting, aggressive behavior in personality)-disordered individuals. In addition to the possibility of central AVP and serotonin interacting to influence human aggression, central AVP may also influence human aggressive behavior through a mechanism independent of central serotonin in personality-disordered subjects.