Nutritional genomics in yeast models.
Nutritional genomics in yeast models.
复制标题
酵母模型中的营养基因组学。
DOI：
10.1016/j.nut.2003.09.026
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sturley,StephenL
中科院分区：
文献类型：
--
作者：
Liu,Ying;Sturley,StephenL
[...] one-third of the yeast genome is a mystery with regard to function. 6 Powerful genetic techniques have been applied in yeast to understand unknown genes (Figure 1). A unique sequence tag (" barcode") has been introduced into each deletion mutant to identify the disruption leading to a rapid means of identifying relative fitness of each strain under a variety of growth conditions. 52 This has proven to be an exceptionally valuable resource for functional genomics in this organism. Because proteins rarely act alone but interact with other proteins, the construction of interaction webs illustrates and elucidates the complexity of biological systems. 53 Genetic interactions (synthetic lethal and suppressor screens) lead to information about overlapping and interacting pathways, and in concert with various genome-wide physical interaction assays represent a powerful approach to understanding the" interactome."
