Matrix metalloproteinase-9 expression of GCTSC in peripheral tissue and central tissue of GCTB
Matrix metalloproteinase-9 expression of GCTSC in peripheral tissue and central tissue of GCTB
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DOI：
10.1002/jcb.26766
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发表时间：
2018-07-01
影响因子：
4
通讯作者：
Ding, Xiao-Yi
中科院分区：
文献类型：
--
作者：
Chen, Liang;Zhang, Ji;Ding, Xiao-Yi
骨巨细胞瘤基质细胞（GCTSC）是骨巨细胞瘤（GCTB）的肿瘤细胞。GCTSC的生物标志物表征对于GCTB靶向药物的选择至关重要。我们认为肿瘤不同部位的GCTSC在不同的环境中发挥的主要功能应该是不同的。GCTSC的生物学行为和分子生物学标志物也应该有所不同。基于这一思路，本课题以MMP-9为切入点，重点对位于中心组织、外周组织的GCTSC进行研究。结果显示，位于中央组织的GCTSC的MMP-9染色级别较低，而多核巨细胞染色级别较高。周围组织基本由GCTSC组成，MMP-9表达及mRNA表达均较强。本研究也为降低GCTB术后复发率提供了线索和启示，针对残留的外周组织进行MMP-9靶向治疗。
Giant cell tumor stromal cell (GCTSC) is the tumor cell of giant cell tumor of bone (GCTB). The biomarkers characterization of GCTSC is critical for the selection of GCTB targeting drugs. We believe the main functions of GCTSC in different part of tumor should be different for different environment. Then the biological behavior and molecular biomarkers of GCTSC should be different as well. Based on this idea, we focused on GCTSC which located in central tissue, peripheral tissue and took MMP-9 as the breakthrough point to carry out research. The results showed MMP-9 staining grade of GCTSC which located in central tissue was slight, whereas multinucleated giant cell staining grade was high. The peripheral tissue was consisted by almost GCTSC with high MMP-9 staining degree and mRNA expression. This study also provided clues and inspiration for reducing GCTB recurrence rate after intralesional curettage with MMP-9 targeted therapy which were aimed at the residual peripheral tissue.