Cells and mediators of inflammation (C-reactive protein, nitric oxide, platelets and neutrophils) in the acute and convalescent phases of uncomplicated Plasmodium vivax and Plasmodium falciparum infection
Cells and mediators of inflammation (C-reactive protein, nitric oxide, platelets and neutrophils) in the acute and convalescent phases of uncomplicated Plasmodium vivax and Plasmodium falciparum infection
复制标题
DOI：
10.1590/s0074-02762012000800012
复制
发表时间：
2012-12-01
期刊：
影响因子：
--
通讯作者：
Oliveira-Ferreira, Joseli de
中科院分区：
文献类型：
--
作者：
Lima-Junior, Josué da Costa;Rodrigues-da-Silva, Rodrigo Nunes;Oliveira-Ferreira, Joseli de
血液学的变化和释放的可溶性介质，特别是C-反应蛋白（CRP）和一氧化氮（NO），在简单的疟疾还没有得到很好的研究，特别是在巴西地区的疾病是地方病。因此，本研究探讨这些因素在急性期（0天）和恢复期（15天）感染恶性疟原虫和间日疟原虫疟疾的患者在巴西亚马逊。采用自动细胞计数法测定血液学参数，ELISA法测定CRP水平，Griess反应法测定血浆NO水平。我们的数据表明，单纯间日疟原虫和恶性疟原虫感染的个体在感染急性期表现出与白色血细胞相似的炎症特征，高条带细胞生成和相当程度的血小板减少。急性间日疟原虫感染组CRP水平高于急性恶性疟原虫感染组，而急性恶性疟原虫感染组和恢复期恶性疟原虫感染组NO水平均高于急性恶性疟原虫感染组。虽然这些介质的变化不能预测疟疾感染，但与疟疾感染相关的血液学方面，特别是血小板和带状细胞的作用，需要进一步研究。
The haematological changes and release of soluble mediators, particularly C-reactive protein (CRP) and nitric oxide (NO), during uncomplicated malaria have not been well studied, especially in Brazilian areas in which the disease is endemic. Therefore, the present study examined these factors in acute (day 0) and convalescent phase (day 15) patients infected with Plasmodium falciparum and Plasmodium vivax malaria in the Brazilian Amazon. Haematologic parameters were measured using automated cell counting, CRP levels were measured with ELISA and NO plasma levels were measured by the Griess reaction. Our data indicate that individuals with uncomplicated P. vivax and P. falciparum infection presented similar inflammatory profiles with respect to white blood cells, with high band cell production and a considerable degree of thrombocytopaenia during the acute phase of infection. Higher CRP levels were detected in acute P. vivax infection than in acute P. falciparum infection, while higher NO was detected in patients with acute and convalescent P. falciparum infections. Although changes in these mediators cannot predict malaria infection, the haematological aspects associated with malaria infection, especially the roles of platelets and band cells, need to be investigated further.