Urinary Metabolic Biomarkers Link Oxidative Stress Indicators Associated with General Arsenic Exposure to Male Infertility In a Han Chinese Population
Urinary Metabolic Biomarkers Link Oxidative Stress Indicators Associated with General Arsenic Exposure to Male Infertility In a Han Chinese Population
复制标题
尿代谢生物标志物将氧化应激指标与中国汉族人群中一般砷暴露与男性不育联系起来
DOI：
10.1021/es402025n
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发表时间：
2013-08-06
影响因子：
11.4
通讯作者：
Zhu, Yong-Guan
中科院分区：
文献类型：
--
作者：
Shen, Heqing;Xu, Weipan;Zhu, Yong-Guan
为了研究一般环境砷（As）暴露会损害男性生育能力的假设，我们设计了一项病例对照研究，检查尿液中不同As物质浓度之间的可能相关性[对照组（n = 151）vs病例组（n = 140）]，尿代谢生物标志物[对照组（n = 158）vs病例组（n = 135）1]和以精液质量差为特征的不育症。从南京医科大学附属医院依次招募区域参与者。无机砷酸盐（As-i（V））暴露水平升高与不孕症相关：与第一个四分位数相比，As-i（V）水平高于中位数的受试者更可能表现为男性特发性不育，其增加的校正比值比（AOR）为4.9 [95%置信区间（CI），1.8-13.6]和13.6（9596 CI，4.8-38.6）分别在第三和第四四分位数（趋势P = 0.000）。其他As物质与不孕风险没有表现出显着的剂量依赖性相关性。尿生物标志物水平与男性不育和As-i（V）浓度相关[对照组（n = 145）vs病例组（n = 123）1，后者的相关性与疾病无关。这些包括酰基肉毒碱，天冬氨酸，和羟基雌酮，这是负相关的不孕症，尿苷和甲基黄嘌呤，这是正相关。总之，我们第一次表明，尿中浓度升高的As-1（V）从一般的As暴露显着相关的男性不育症，作为物种可能会通过氧化应激和性激素干扰机制，如相关的生物标志物所示的毒性。
To investigate the hypothesis that general environmental arsenic (As) exposure can impair male fertility, we designed a case-control study examining possible correlations between the concentrations of different As species in urine [controls (n = 151) vs cases (n = 140)], urinary metabolic biomarkers [controls (n = 158) vs cases (n = 135)1 and infertility characterized by poor semen quality. Regional participants were recruited sequentially from the affiliated hospitals of Nanjing Medical University. Elevated inorganic arsenate (As-i(V)) exposure was associated with infertility: in comparison with the first quartile, subjects with As-i(V) levels above the median were more likely to exhibit male idiopathic infertility with increasing adjusted odds ratios (AOR) of 4.9 [95% confidence interval (CI), 1.8-13.6] and 13.6 (9596 CI, 4.8-38.6) at the third and fourth quartiles (P = 0.000 for trend), respectively. Other As species did not exhibit a significant dose-dependent correlation with infertility risk. Levels of urinary biomarkers correlated with both male infertility and As-i(V) concentrations [controls (n = 145) vs cases (n = 123)1 the latter correlation was independent of disease. These included acylcarnitines, aspartic acid, and hydroxyestrone, which were negatively associated with infertility, and uridine and methylxanthine, which were positively associated. In conclusion, for the first time we show that elevated urinary concentrations of As-i(V) from general As exposure are significantly associated with male infertility, and As species may exert toxicity via oxidative stress and sexual hormone disrupting mechanisms, as indicated by related biomarkers.