Birth defects among offspring of firemen.
Birth defects among offspring of firemen.
复制标题
消防员后代的出生缺陷。
DOI：
10.1093/oxfordjournals.aje.a115500
复制
发表时间：
1990
影响因子：
5
通讯作者：
P. Baird
中科院分区：
文献类型：
--
作者：
A. Olshan;K. Teschke;P. Baird
作者进行了一项探索性的病例对照研究，研究对象是父亲从事消防工作与后代出生缺陷风险之间的关系。通过在不列颠哥伦比亚省以人口为基础的登记，在1952 - 1973年期间确定了22 192名出生缺陷的活产婴儿。进行了两项比较来评估消防员后代的风险：1）使用匹配的对照组（每例两人）与从事其他职业的父亲的后代的风险进行比较，2）与警察后代的风险进行比较。在研究的20个出生缺陷组中，发现父亲作为消防员的职业与出生缺陷有关联（相对于所有其他职业），观察到室间隔缺损的风险增加（OR = 2.70，95% CI 1.02-7.18）和房间隔缺损（OR = 5.91，95% CI 1.60-21.83）。与警察相比，消防员生下室间隔缺损（OR = 4.68，95% CI 1.66-13.17）和房间隔缺损（OR = 3.76，95% CI 1.40-10.07）的风险增加。对这些心脏缺陷的病因分类进行分析，发现消防员的优势比也有类似的增加。
The authors conducted an exploratory case-control study of paternal employment as a fire fighter and the risk of birth defects among offspring. By means of a population-based registry in British Columbia, 22,192 liveborn children with birth defects were identified for the period, 1952-1973. Two comparisons were made to evaluate the risk among offspring of firemen: 1) comparison with the risk among offspring of fathers employed in other occupations using a matched (two per case) control group, and 2) comparison with the risk among offspring of policemen. Among the 20 birth defect groups studied, an association was found for paternal employment as a fire fighter (relative to all other occupations) and increased risks were observed for ventricular septal defects (odds ratio (OR) = 2.70, 95% confidence interval (Cl) 1.02-7.18) and atrial septal defects (OR = 5.91, 95% Cl 1.60-21.83) among offspring. When compared with policemen, firemen had increased risks of having a child with a ventricular septal defect (OR = 4.68, 95% Cl 1.66-13.17) and atrial septal defect (OR = 3.76, 95% Cl 1.40-10.07). Analyses using a pathogenetic classification for these heart defects yielded similar increased odds ratios for firemen.