The role of the mitogen-activated protein kinase cellular signaling pathway in tumor cell survival and apoptosis
The role of the mitogen-activated protein kinase cellular signaling pathway in tumor cell survival and apoptosis
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DOI：
10.1358/dnp.2004.17.4.829050
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发表时间：
2004-05-01
影响因子：
--
通讯作者：
Whartenby, KA
中科院分区：
文献类型：
--
作者：
Freeman, SM;Whartenby, KA
许多信号通路在肿瘤细胞存活和生长的起始和维持中是重要的。有丝分裂原活化蛋白激酶是一个不同谱系的激酶家族，被认为在肿瘤生长和转移中是重要的。这些途径提供了对肿瘤细胞如何逃避不同药物杀伤的深入了解。此外，由于这些途径参与肿瘤细胞的存活，因此正在测试几种抑制它们的策略用于新型癌症疗法。本文综述了这些途径在癌症中的作用的证据和治疗的现状。(C)2004年，《科学》杂志。All rights reserved.
A number of signaling pathways are important in the initiation and maintenance of tumor cell survival and growth. Mitogen activated protein kinases are a family of kinases of different lineages that are thought to be important in tumor growth and metastasis. These pathways provide insight into how tumor cells may escape killing by different agents. In addition, since these pathways are involved in tumor cell survival, several strategies to inhibit them are being tested for novel cancer therapies. This review summarizes the evidence for the role of these pathways in cancer and the current status of therapies. (C) 2004 Prous Science. All rights reserved.