Predictors of pre-eclampsia in women at high risk
Predictors of pre-eclampsia in women at high risk
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DOI：
10.1016/s0002-9378(98)70194-2
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发表时间：
1998-10-01
影响因子：
9.8
通讯作者：
Roberts, J
中科院分区：
文献类型：
--
作者：
Caritis, S;Sibai, B;Roberts, J
目的：我们评估了几个变量，作为一组具有高风险女性的预兆风险的预测因素。研究：我们研究了2503名患有糖尿病的女性在一项比较阿司匹林和安慰剂的多中心研究中，预防先兆子痫。我们评估了多个变量，用于使用单变量和多变量分析来预测前宾夕法尼亚的风险。结果：随机分配时的平等和平均动脉压最可预测益酮前风险的风险。风险为8％，平均动脉压为85 mm Hg（相对风险和95％置信区间3.3 [2.4至4.4]）。无效患者的子痫前期风险为26％，而在宿害受试者中为17％（相对风险和95％的置信区间1.5 [1.3-1.8]）。结论：发现第二种孕期平均动脉压会影响前兆子痫的风险。表明先兆子痫的病理生理过程是在此之前开始的。
OBJECTIVE: We assessed several variables as predictors for pre-eclampsia risk in a group of women at high risk.STUDY DESIGN: We studied 2503 women with either diabetes mellitus, chronic hypertension, multifetal gestation, or pre-eclampsia in a previous pregnancy who participated in a multicenter study comparing aspirin and placebo in preventing pre-eclampsia. We evaluated multiple variables for predicting pre-eclampsia risk with use of univariate and multivariable analysis.RESULTS: Parity and mean arterial pressure at randomization were most predictive of pre-eclampsia risk. The risk was 8% with a mean arterial pressure at enrollment of 85 mm Hg (relative risk and 95% confidence interval 3.3 [2.4 to 4.4]). The risk of pre-eclampsia was 26% in nulliparous patients versus 17% in parous subjects (relative risk and 95% confidence interval 1.5 [1.3-1.8]).CONCLUSIONS: The finding that second-trimester mean arterial pressure affects pre-eclampsia risk suggests that the pathophysiologic process of preeclampsia is initiated before that time.