The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice.
The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice.
复制标题
产前给予多氯联苯对小鼠神经行为发育的影响。
DOI：
10.1016/0013-9351(79)90122-1
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发表时间：
1979
影响因子：
8.3
通讯作者：
G. Lucier
中科院分区：
文献类型：
--
作者：
H. Tilson;G. J. Davis;J. Mclachlan;G. Lucier
在成年期进行测试时，在子宫内暴露于 3,4,3',4'-四氯联苯 (TCB) 的白化小鼠表现出神经毒性迹象。受影响最严重的受试者（TCB 旋转者）表现出神经行为综合征，包括间歇性刻板转圈、摇头和多动。 TCB 旋转者被发现在昼间的黑暗阶段明显过度活跃，并表现出前肢握力、穿过线材的能力、视觉位置反应和单向回避能力受损。一些小鼠没有表现出旋转综合症（TCB-非旋转者），但被发现在穿过线材和回避获取方面存在缺陷。没有发现暴露于 TCB 的小鼠对各种刺激的神经肌肉反射减弱。组织分布研究表明，在产前暴露后，成年小鼠中未检测到 TCB 水平。这些实验的结果表明，产前接触 TCB 可以影响成年小鼠的神经行为功能，并且在某些情况下，在没有临床毒性症状的情况下也可以观察到这种影响。
When tested at adulthood, albino mice exposedin uteroto 3,4,3′,4′-tetrachlorobiphenyl (TCB) demonstrated signs of neurotoxicity. The most severely affected subjects (TCB-spinners) displayed a neurobehavioral syndrome consisting of intermittent stereotypic circling, head bobbing, and hyperactivity. TCB-spinners were found to be markedly hyperactive during the dark phase of the diurnal phase and showed impaired forelimb grip strength, ability to traverse a wire rod, visual placement responding, and acquisition of one-way avoidance. Some mice did not display the spinning syndrome (TCB-nonspinners), but were found to be deficient in traversing a wire rod and avoidance acquisition. None of the TCB-exposed mice were found to have depressed neuromuscular reflexes in response to a variety of stimuli. Tissue distribution studies demonstrated that TCB levels were not detectable in adult mice following prenatal exposures. The results of these experiments demonstrate that prenatal exposure to TCB can influence neurobehavioral functioning of mice during adulthood and, in some cases, such effects can be observed in the absence of clinical signs of toxicity.