Association of the Elevated Red Blood Cell Distribution Width with the Risk of Developing Diabetes Mellitus
Association of the Elevated Red Blood Cell Distribution Width with the Risk of Developing Diabetes Mellitus
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DOI：
10.2169/internalmedicine.55.5956
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发表时间：
2016-01-01
影响因子：
1.2
通讯作者：
Wan Lifang
中科院分区：
文献类型：
--
作者：
Gang, Li;Wan Lifang
目的本研究的目的是确定是否RDW变异系数（CV）的水平升高与糖尿病（DM）的发展在健康的中老年人individual.Method人群中，我们进行了一项回顾性队列研究。根据RDW-CV四分位数对2,688名基线时无DM诊断、空腹血糖受损或贫血的个体进行分组，并记录各组4年期间DM的发病情况。结果RDW-CV与腰围、RDW-CV与HbA 1c的相关系数分别为0.114和0.133。与RDW-CV四分位数I（低）相比，RDW-CV四分位数II、III和IV（高）中未来DM的相对风险分别为1. 9 [95%置信区间（CI）1. 0 - 3. 6，p= 0. 057]、1. 6（95% CI 0. 8 - 3. 0，p= 0. 157）和2. 2（95% CI 1. 2 - 4. 0，p= 0. 015）。在调整性别、年龄、腰围、血红蛋白A1 c、甘油三酯、高密度脂蛋白胆固醇（HDL-C）和高敏C反应蛋白后，RDW-CV最高和最低四分位数的多变量相对危险度为1.8（95%CI，1.1-3.4，p=0.046）。
Objective The aim of this study was to determine whether elevated levels of RDW-coefficient of variation (CV) are associated with the development of diabetes mellitus (DM) in a population of healthy middle- and old-aged individuals.Method We conducted a retrospective cohort study. A total of 2,688 individuals (aged 49-66 years) without a DM diagnosis, impaired fasting glucose, or anemia at baseline were grouped according to the RDW-CV quartile, and the onset of DM during a 4-year period was recorded for each group.Results The correlation coefficients for the RDW-CV and waist circumference and for the RDW-CV and HbA1c were 0.114 and 0.133, respectively. The relative risks of future DM in RDW-CV quartiles II, III, and IV (high) compared with RDW-CV quartile I (low) were 1.9 [95% confidence interval (CI) 1.0-3.6, p=0.057], 1.6 (95% CI 0.8-3.0, p=0.157), and 2.2 (95% CI 1.2-4.0, p=0.015), respectively. After adjusting for sex, age, waist circumference, hemoglobin A1c, triglycerides, high density lipoprotein-cholesterol (HDL-C), and high-sensitivity C-reactive protein, the multivariate relative risk for the highest vs. the lowest RDW-CV quartile was 1.8 (95% CI, 1.1-3.4, p=0.046).Conclusion These data indicate that an elevated RDW-CV is associated with an increased incidence of DM.