Intraspinal course of descending serotoninergic pathways innervating the rodent dorsal horn and lamina X.
Intraspinal course of descending serotoninergic pathways innervating the rodent dorsal horn and lamina X.
复制标题
神经支配啮齿类动物背角和 X 板的下降 5-羟色胺能通路的椎内路线。
DOI：
10.1002/cne.902860208
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Light,AR
中科院分区：
文献类型：
--
作者：
Bullitt,E;Light,AR
虽然许多研究已经讨论了从脑干投射到脊髓的轴突能通路，但这些下行轴突的椎管内过程仍然是一个争论的问题。传统免疫组织化学方法的困难之一是对结果的解释是主观的。因此，我们采用了计算机辅助图像处理系统来提供啮齿动物背角和X板尾侧至单侧胸脊髓切断术内5-羟色胺免疫反应性的客观测量，以建立脊髓内下行的5-羟色胺能纤维。和相机lucida绘图表明，主要的肾上腺素能通路终止于背角内的课程单侧内的背外侧索的背侧部分。胸背角可能比腰背角从对侧接收稍大的贡献。X板层接受来自同侧背外侧索内下降的纤维和来自更位于腹侧的同侧通路的5-羟色胺能神经支配，并且它还含有来自其他来源的5-羟色胺。
Although numerous studies have discussed serotoninergic pathways projecting from the brainstem to the spinal cord, the intraspinal course of these descending axons remains a matter of debate. One of the difficulties with traditional immunohistochemical methods is that the interpretation of results has been subjective. We have therefore employed a computer‐assisted imageprocessing system to provide objective measurements of serotonin immunoreactivity within the rodent dorsal horn and lamina X caudal to unilateral thoracic cordotomy in order to establish the intraspinal course of descending serotoninergic fibers.Lesion analysis combined with computer‐determined optical density measurements, high‐power microscopic examination, and camera lucida drawings demonstrated that the predominant serotoninergic pathway terminating within the dorsal horn courses unilaterally within the dorsal portion of the dorsolateral funiculus. The thoracic dorsal horn may receive a slightly greater contribution from the contralateral side than the lumbar dorsal horn. Lamina X receives serotoninergic innervation both from fibers descending within the ipsilateral dorsolateral funiculus and from more ventrally located ipsilateral pathways, and it also contains serotonin derived from other sources.