The Coupled Chemical and Physical Dynamics Model of MALDI
The Coupled Chemical and Physical Dynamics Model of MALDI
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DOI：
10.1146/annurev-anchem-071015-041750
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Knochenmuss, Richard
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文献类型：
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作者：
Knochenmuss, Richard
紫外光基质辅助激光解吸/电离(MALDI)的物理和化学耦合动力学模型再现和解释了MALDI的各种现象。综述了该模型的基本原理和基本原理，包括初级和次级反应步骤的光物理、动力学和热力学。实验结果与模型预测进行了比较，以说明模型的基础、烧蚀和电离的耦合、基质的异同和共性、二次电荷转移反应、两极电离、通量和浓度依赖关系以及抑制和增强效应。
The coupled physical and chemical dynamics model of ultraviolet matrix-assisted laser desorption/ionization (MALDI) has reproduced and explained a wide variety of MALDI phenomena. The rationale behind and elements of the model are reviewed, including the photophysics, kinetics, and thermodynamics of primary and secondary reaction steps. Experimental results are compared with model predictions to illustrate the foundations of the model, coupling of ablation and ionization, differences between and commonalities of matrices, secondary charge transfer reactions, ionization in both polarities, fluence and concentration dependencies, and suppression and enhancement effects.