Ring box protein-1 is associated with a poor prognosis and tumor progression in esophageal cancer
Ring box protein-1 is associated with a poor prognosis and tumor progression in esophageal cancer
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DOI：
10.3892/ol.2020.11840
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发表时间：
2020-09-01
期刊：
影响因子：
2.9
通讯作者：
Sho, Masayuki
中科院分区：
文献类型：
--
作者：
Kunishige, Tomohiro;Migita, Kazuhiro;Sho, Masayuki
Ring box protein-1 (RBX1) is an essential component of the S-phase kinase-associated protein, Cullin and F-box containing ubiquitin ligases. Overexpression of RBX1 has been reported in several cancer types; however, little is known regarding the prognostic value and role of RBX1 in esophageal cancer.本研究使用免疫组织化学方法检查了 120 名接受根治性食管切除术的食管癌 (EC) 患者和 61 名接受多西他赛、顺铂和 5-氟尿嘧啶 (5-FU; DCF) 新辅助联合化疗的食管癌患者。 All specimens were classified into two groups according to the percentage of RBX1-positive tumor cells. In addition, the impact of RBX1 expression on cancer cell proliferation was analyzedin vitrousing a small interfering RNA silencing technique. RBX1 expression levels showed significant differences according to tumor size (P
Ring box protein-1 (RBX1) is an essential component of the S-phase kinase-associated protein, Cullin and F-box containing ubiquitin ligases. Overexpression of RBX1 has been reported in several cancer types; however, little is known regarding the prognostic value and role of RBX1 in esophageal cancer. The present study examined 120 patients with esophageal cancer (EC) who underwent curative esophagectomy and 61 patients with EC who underwent neoadjuvant combination chemotherapy with docetaxel, cisplatin and 5-fluorouracil (5-FU; DCF) using immunohistochemistry. All specimens were classified into two groups according to the percentage of RBX1-positive tumor cells. In addition, the impact of RBX1 expression on cancer cell proliferation was analyzedin vitrousing a small interfering RNA silencing technique. RBX1 expression levels showed significant differences according to tumor size (P