Interactions between cigarette smoking and XPC-PAT genetic polymorphism enhance bladder cancer risk
Interactions between cigarette smoking and XPC-PAT genetic polymorphism enhance bladder cancer risk
复制标题
吸烟与 XPC-PAT 基因多态性之间的相互作用会增加膀胱癌风险
DOI：
10.3892/or.2012.1759
复制
发表时间：
2012-07-01
期刊：
影响因子：
4.2
通讯作者：
Chen, Zhiwen
中科院分区：
文献类型：
--
作者：
Liu, Yang;Wang, Huanhuan;Chen, Zhiwen
遗传多态性:;导致DNA修复能力降低的XPC基因突变可能会增加膀胱癌的易感性。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，研究了600名中国汉族膀胱癌患者和609名健康对照者的XPC基因（PAT、Ala499Val和Lys939Gln）的3种多态性。吸烟与膀胱癌风险显著增加相关（OR, 2.48; 95% CI, 1.91-3.21）。重度吸烟者（OR, 3.09, 95% CI, 2.24-4.25）比轻度吸烟者（OR, 1.91, 95% CI, 1.37-2.68）的风险更大。在XPC的三个多态性中，只有XPC- pat变异基因型表现出膀胱癌风险的显著增加。当检测总吸烟暴露-基因相互作用时，这三种多态性在从不吸烟者中没有表现出任何显著影响，但在轻度或重度吸烟者中表现出显著的剂量-反应关联。特别是，XPC-PAT多态性（(+/-)）显著增加膀胱癌的风险(OR, 2.56, 95% CI, 1.56-4.21， P
Inherited polymorphism:; in the XPC gene that lead to a reduction in DNA repair capacity may increase susceptibility to bladder cancer. We investigated three polymorphisms of the XPC gene (PAT, Ala499Val and Lys939Gln) in 600 subjects with bladder cancer and in 609 healthy controls by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a Chinese Han population. Smoking was associated with a significant increase in the risk for bladder cancer (OR, 2.48; 95% CI, 1.91-3.21). The risk was greater among heavy smokers (OR, 3.09, 95% CI, 2.24-4.25) compared to light smokers (OR, 1.91, 95% CI, 1.37-2.68). In three polymorphisms of XPC, only the XPC-PAT variant genotype exhibited a significantly increased risk for bladder cancer. When the total smoking exposure-gene interaction was examined, the three polymorphisms did not exhibit any significant effect in never smokers but a significant dose-response association in light or heavy smokers. Especially, the bladder cancer risk was significantly elevated among the polymorph isms of XPC-PAT((+/-)) (OR, 2.56, 95% CI, 1.56-4.21, P