Preconception paternal comorbidities and offspring birth defects: Analysis of a large national data set.
Preconception paternal comorbidities and offspring birth defects: Analysis of a large national data set.
复制标题
孕前父亲合并症和后代出生缺陷：大型国家数据集的分析。
DOI：
10.1002/bdr2.2082
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发表时间：
2023
影响因子：
2.1
通讯作者：
Eisenberg,MichaelL
中科院分区：
文献类型：
--
作者：
Yu,Bo;Zhang,ChiyuanAmy;Li,Shufeng;Chen,Tony;Mulloy,Evan;Shaw,GaryM;Eisenberg,MichaelL
背景尽管父亲贡献了一半的基因组给孩子，父亲因素和出生缺陷之间的关联知之甚少。ObjectivesTo调查孕前父亲健康和后代出生缺陷之间的关联。材料和方法我们利用IBM Marketscan研究数据库对一项全国性队列研究进行了分析，其中包括2007年至2016年美国报销私人医疗索赔的数据。父亲的合并症之间的潜在关联，作为衡量代谢综合征（MetS）的组成部分，和任何出生缺陷的后代进行了analysed.ResultsOf 712,774活产确定，21.2%的孩子出生的父亲至少有一个组成部分的代谢综合征（MetS ≥1）之前的概念。与无代谢综合征组分的父亲所生的婴儿相比，有更多代谢综合征组分的父亲所生的心脏出生缺陷婴儿的百分比略高（MetS = 1，OR [95% CI]：1.07 [1.01-1.13]; MetS ≥2，1.17 [1.08-1.26]，与MetS = 0相比）。同样，患有两种或两种以上代谢综合征的父亲所生的婴儿中，（MetS ≥2，OR [95% CI]：1.45 [1.22-1.71]）.讨论和结论在这项基于私人保险索赔的研究中，我们发现在怀孕前患有代谢综合征相关疾病的父亲生下受出生缺陷影响的孩子的风险增加，尤其是心脏和呼吸缺陷，这种关联不受父亲年龄或评估的母亲因素的影响。
BackgroundDespite the fact that the father contributes half the genome to a child, associations between paternal factors and birth defects are poorly understood.ObjectivesTo investigate the association between preconception paternal health and birth defects in the offspring.Materials and MethodsWe conducted analysis of a national cohort study utilizing the IBM Marketscan Research Database, which includes data on reimbursed private healthcare claims in the United States from 2007 to 2016. The potential association between paternal comorbidities, as measured by the components of metabolic syndrome (MetS), and any birth defect in the offspring was analyzed.ResultsOf the 712,774 live births identified, 21.2% of children were born to fathers with at least one component of the metabolic syndrome (MetS ≥1) prior to conception. Compared to infants born to fathers with no components of the metabolic syndrome, a modestly higher percentage of infants with cardiac birth defects were born to fathers with more components of MetS (MetS = 1, OR [95% CI]: 1.07 [1.01–1.13]; MetS ≥2, 1.17 [1.08–1.26], in comparison to MetS = 0) after adjusting for maternal and paternal factors. Similarly, a higher percentage of infants with respiratory defects were born to fathers with two or more components of metabolic syndrome (MetS ≥2, OR [95% CI]: 1.45 [1.22–1.71]).Discussion and ConclusionIn this private insurance claims‐based study, we found that fathers with metabolic syndrome‐related diseases before conception were at increased risk for having a child affected by birth defects, especially cardiac and respiratory defects, and this association was not influenced by paternal age or assessed maternal factors.