EXPRESSION OF HUMAN B CELL-ASSOCIATED ANTIGENS ON LEUKEMIAS AND LYMPHOMAS - A MODEL OF HUMAN B-CELL DIFFERENTIATION
EXPRESSION OF HUMAN B CELL-ASSOCIATED ANTIGENS ON LEUKEMIAS AND LYMPHOMAS - A MODEL OF HUMAN B-CELL DIFFERENTIATION
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DOI：
10.1182/blood.v63.6.1424.1424
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发表时间：
1984-01-01
期刊：
影响因子：
20.3
通讯作者：
NADLER, LM
中科院分区：
文献类型：
--
作者：
ANDERSON, KC;BATES, MP;NADLER, LM
利用一系列定义 B 细胞限制性抗原和相关抗原的单克隆抗体，试图表征 B 谱系肿瘤并将这些肿瘤与 B 细胞分化阶段联系起来。先前显示为限制于正常 B 淋巴细胞的 B 细胞抗原同样仅在 B 细胞恶性肿瘤中表达。在其他谱系的肿瘤中也发现了与 B 细胞相关的抗原。根据细胞表面表型，B细胞来源的肿瘤根据恶性肿瘤细胞的分化程度分为3个主要亚组：前B细胞期（非T急性淋巴细胞白血病和淋巴母细胞危象的慢性粒细胞白血病）；中期 B 细胞阶段（慢性淋巴细胞白血病、低分化淋巴瘤）；和分泌性 B 细胞（大阶段细胞淋巴瘤和浆细胞肿瘤）。根据这组 B 细胞限制性抗原和 B 细胞相关抗原的细胞表面表达，恶性 B 细胞与其正常细胞对应物相关。
A series of monoclonal antibodies that define B cell restricted and associated antigens was utilized in an attempt to characterize tumors of B lineage and to relate these tumors to B cell differentiative stages. Antigens that were previously shown to be B cell restricted on normal B lymphocytes were similarly expressed only on B cell malignancies. Antigens that were B cell associated were also found on tumors of other lineages. On the basis of cell surface phenotypes, tumors of B cell origin were divided into 3 major subgroups, which corresponded to the level of differentiation of the malignant tumor cell: pre-B cell stage (non-T acute lymphoblastic leukemia and chronic myelocytic leukemia in lymphoid blast crisis); the mid-B cell stage (chronic lymphocytic leukemia, poorly differentiated lymphomas); and secretory B cell (large stage cell lymphomas and plasma cell tumors). The malignant B cell was related to its normal cellular counterpart on the basis of cells urface expression of this panel B cell-restricted and B cell-associated antigens.