Fiber optic photoacoustic probe with ultrasonic tracking for guiding minimally invasive procedures
Fiber optic photoacoustic probe with ultrasonic tracking for guiding minimally invasive procedures
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DOI：
10.1117/12.2182647
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发表时间：
2015-06
期刊：
影响因子：
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通讯作者：
W. Xia;C. Mosse;R. Colchester;J. Mari;Daniil I. Nikitichev;S. West;S. Ourselin;P. Beard;A. Desjardins
中科院分区：
文献类型：
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作者：
W. Xia;C. Mosse;R. Colchester;J. Mari;Daniil I. Nikitichev;S. West;S. Ourselin;P. Beard;A. Desjardins
在广泛的临床手术中，准确放置针头和导管等医疗器械对于优化患者结局至关重要。超声成像通常用于指导微创手术，因为它可以提供患者解剖结构和医疗器械的实时可视化。然而，这种模态可能为软组织提供低的图像对比度，并且相对于进入的超声波束成陡峭角度的医疗设备的可视化差。光声传感器可以提供关于组织发色团的空间分布的信息，这对于指导微创手术可能是有价值的。在这项研究中，开发了一种用于使用光声传感引导微创手术的系统。该系统包括具有三根光纤的微型光声探头：一根光纤具有光声激发组织的裸露端，第二根光纤用于光声激发远端处的光吸收涂层以传输超声，第三根光纤具有法布里-珀罗腔，用于接收超声。光声探头的位置是用超声跟踪确定的，超声跟踪涉及从组织表面的线性阵列超声成像探头发射脉冲，并用光声探头中的光纤超声接收器接收脉冲。光声传感的轴向分辨率优于70 μm，跟踪精度在轴向和横向均优于1 mm。通过平移光声探头，从不同的空间位置获得深度扫描，并使用频域算法重建二维图像。
In a wide range of clinical procedures, accurate placement of medical devices such as needles and catheters is critical to optimize patient outcomes. Ultrasound imaging is often used to guide minimally invasive procedures, as it can provide real-time visualization of patient anatomy and medical devices. However, this modality can provide low image contrast for soft tissues, and poor visualization of medical devices that are steeply angled with respect to the incoming ultrasound beams. Photoacoustic sensors can provide information about the spatial distributions of tissue chromophores that could be valuable for guiding minimally invasive procedures. In this study, a system for guiding minimally invasive procedures using photoacoustic sensing was developed. This system included a miniature photoacoustic probe with three optical fibers: one with a bare end for photoacoustic excitation of tissue, a second for photoacoustic excitation of an optically absorbing coating at the distal end to transmit ultrasound, and a third with a Fabry-Perot cavity at the distal end for receiving ultrasound. The position of the photoacoustic probe was determined with ultrasonic tracking, which involved transmitting pulses from a linear-array ultrasound imaging probe at the tissue surface, and receiving them with the fiber-optic ultrasound receiver in the photoacoustic probe. The axial resolution of photoacoustic sensing was better than 70 μm, and the tracking accuracy was better than 1 mm in both axial and lateral dimensions. By translating the photoacoustic probe, depth scans were obtained from different spatial positions, and two-dimensional images were reconstructed using a frequency-domain algorithm.