Identifying Cognitive Problems in Children and Adolescents with Depression Using Computerized Neuropsychological Testing
Identifying Cognitive Problems in Children and Adolescents with Depression Using Computerized Neuropsychological Testing
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DOI：
10.1080/09084280903526083
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发表时间：
2010-01-01
影响因子：
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通讯作者：
Roberge, Marie-Claude
中科院分区：
文献类型：
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作者：
Brooks, Brian L.;Iverson, Grant L.;Roberge, Marie-Claude
儿童和青少年的抑郁症会对认知功能、社会发展和学习成绩产生负面影响。本研究的目的是确定是否电脑电池的神经心理测试可以检测神经认知障碍的儿童和青少年抑郁症。参与者包括30名9至17岁（M=14.6，SD=2.1）的儿童和青少年，临床诊断为抑郁症。健康对照组参与者在年龄、教育程度、性别、种族、主要语言、惯用手和自我报告的计算机熟悉程度方面进行了单独匹配。所有参与者完成了中枢神经系统生命体征计算机化成套检查。这七个测试组合产生23个测试分数和5个领域分数（记忆，心理速度，反应时间，复杂注意力和认知灵活性）。与匹配的对照组相比，患有抑郁症的儿童和青少年在记忆（Cohen的d= 0.43）和复杂注意力领域（d= 0.58）的表现更差。在个体测试分数上，患有抑郁症的儿童和青少年在延迟言语记忆（d= 0.63），延迟视觉记忆（d= 0.34），反应时间（d= 0.34 - 0.53）和复杂注意力任务的准确性/抑制（d= 0.49 - 0.65）方面表现较差。当同时考虑五个领域的分数时，患有抑郁症的儿童和青少年更有可能有两个或更多的分数处于或低于第5百分位数（p=.05）。患有抑郁症的儿童和青少年在这种计算机化的成套测试中存在处理速度降低、言语信息记忆和执行功能下降的问题，这是一种可行的神经心理学筛查方法。
Depression in children and adolescents can negatively impact cognitive functioning, social development, and academic performance. The purpose of this study was to determine whether a computerized battery of neuropsychological tests could detect neurocognitive difficulties in children and adolescents with depression. Participants included 30 children and adolescents between the ages of 9 and 17 years (M=14.6, SD=2.1) with a clinical diagnosis of depression. Healthy control participants were individually matched on age, education, sex, race, primary language, handedness, and self-reported computer familiarity. All participants completed the Central Nervous System Vital Signs computerized battery. This battery of seven tests yields 23 test scores and 5 domain scores (Memory, Psychomotor Speed, Reaction Time, Complex Attention, and Cognitive Flexibility). Children and adolescents with depression performed worse on the Memory (Cohen's d=.43) and Complex Attention domains (d=.58) than matched controls. On the individual test scores, children and adolescents with depression performed worse on delayed verbal memory (d=.63), delayed visual memory (d=.34), measures of reaction time (d=.34-.53), and accuracy/inhibition on complex attention tasks (d=.49-.65). When considering the five domain scores simultaneously, children and adolescents with depression were more likely to have two or more scores at or below the 5th percentile (p=.05). Children and adolescents with depression have problems with reduced processing speed, memory for verbal information, and executive functioning on this computerized battery of tests, which represents a feasible method for neuropsychological screening.