Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells
Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells
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Wnt信号的激活抑制Notch在胃癌细胞中的促凋亡作用
DOI：
10.3892/mmr.2013.1412
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发表时间：
2013-06-01
影响因子：
3.4
通讯作者：
Guan, Yifu
中科院分区：
文献类型：
--
作者：
Li, Hong;Mo, Juan;Guan, Yifu
Notch和Wnt信号传导在发育和疾病的调节中发挥着关键作用。此前有几项研究报道，Notch可能是治疗各种类型人类癌症的治疗靶点。在这项研究中，我们报告Notch 1的激活抑制BGC-823胃癌细胞的增殖。然而，Wnt/β-catenin信号通路的激活促进BGC-823细胞的生长。两条信号通路的联合激活促进了BGC-823细胞的增殖。这些数据表明Wnt信号的激活克服了Notch在BGC-823胃癌细胞中的促凋亡作用。
Notch and Wnt signaling play critical roles in the regulation of development and diseases. Several studies have previously reported that Notch may be a therapeutic target in the treatment of various types of human cancer. In this study, we report that activation of Notch1 inhibits the proliferation of BGC-823 gastric cancer cells. However, the activation of the Wnt/beta-catenin signaling pathway promotes the growth of BGC-823 cells. Furthermore, the combinational activation of the two signaling pathways promotes the proliferation of BGC-823 cells. These data suggest that the activation of Wnt signaling overcomes the pro-apoptotic role of Notch in BGC-823 gastric cancer cells.