Inhibitory effects of sialic acid- or N-acetylglucosamine-specific lectins on histamine release induced by compound 48/80, bradykinin and a polyethylenimine in rat peritoneal mast cells.
Inhibitory effects of sialic acid- or N-acetylglucosamine-specific lectins on histamine release induced by compound 48/80, bradykinin and a polyethylenimine in rat peritoneal mast cells.
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唾液酸或 N-乙酰氨基葡萄糖特异性凝集素对化合物 48/80、缓激肽和聚乙烯亚胺在大鼠腹膜肥大细胞中诱导的组胺释放的抑制作用。
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
T. Suzuki
中科院分区：
文献类型：
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作者：
K. Matsuda;A. Niitsuma;M. Uchida;T. Suzuki
研究了七种具有不同糖特异性的凝集素对非免疫刺激诱导的大鼠腹膜肥大细胞释放组胺的影响。使用的非免疫刺激是三种基本促分泌剂：化合物48/80、缓激肽和PEI6（分子量为600的聚乙烯亚胺）。在这项研究中，我们观察到Macckia amurensis促细胞分裂原和马铃薯凝集素（100微克/ml，37℃，10分钟）对组胺释放的抑制作用，它们分别对唾液酸-α 2,3-N-乙酰半乳糖胺（Sia α 2,3GalNAc）和N-乙酰氨基葡萄糖（GlcNAc）低聚物具有特异性。商陆促细胞分裂素和接骨木凝集素的作用不同。粘蛋白型寡糖特异性的三种凝集素抑制化合物48/80诱导的组胺释放，但不抑制缓激肽或PEI6诱导的组胺释放。由于缓激肽和 PEI6 进一步增强了化合物 48/80 诱导的组胺释放，因此它们部分共享相同的信号传导途径。如前所述(Jpn. J. Pharmacol. 57, 79-90, 1991)，具有平分GlcNAc和Sia残基的糖蛋白似乎是化合物48/80、缓激肽和PEI6的作用位点之一。除了直接激活百日咳毒素敏感的 G 蛋白之外，我们提出了另一种通过大鼠腹膜肥大细胞上的特定糖蛋白进行非免疫刺激的机制。涉及的表观糖残基是天冬酰胺连接的寡糖与Sia（特别是Sia α 2,3Gal）、GlcNAc 寡聚物和/或平分GlcNAc。
The effects of seven lectins with various sugar-specificities on histamine release from rat peritoneal mast cells induced by non-immunologic stimuli were studied. The non-immunologic stimuli used were three basic secretagogues, compound 48/80, bradykinin and PEI6 (polyethylenimine with a molecular weight of 600). In this study, we observed inhibition of the histamine release by Macckia amurensis mitogen and Solanum tuberosum agglutinin (100 micrograms/ml at 37 degrees C for 10 min), which are specific for sialic acid-alpha 2,3-N-acetyl galactosamine (Sia alpha 2,3GalNAc) and N-acetyl glucosamine (GlcNAc) oligomers, respectively. The effects of Phytolacca americana mitogen and Sambucus sieboldiana agglutinin were different. Three lectins specific for mucin type oligosaccharides inhibited the histamine release induced by compound 48/80 but not that induced by bradykinin or PEI6. Since bradykinin and PEI6 additively enhanced the histamine release induced by compound 48/80, they partially shared the same signalling pathways. Glycoproteins with bisecting GlcNAc and Sia residues, as described previously (Jpn. J. Pharmacol. 57, 79-90, 1991), seemed to be one of the action sites for compound 48/80, bradykinin and PEI6. In addition to the direct activation of the pertussis toxin-sensitive G proteins, we propose another mechanism of non-immunologic stimuli via specific glycoproteins on rat peritoneal mast cells. The apparent sugar residues involved were asparagine-linked oligosaccharides with Sia (especially Sia alpha 2,3Gal), GlcNAc oligomers and/or bisecting GlcNAc.
过敏毒素 C3a 刺激肥大细胞的作用机制。
DOI：
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发表时间：
1992
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Mousli,M;Hugli,TE;Landry,Y;Bronner,C
通讯作者：
Bronner,C
影响因子：
2.7
作者：
N. Shibuya;K. Tazaki;Zhiwei Song;G. Tarr;I. Goldstein;W. Peumans
通讯作者：
N. Shibuya;K. Tazaki;Zhiwei Song;G. Tarr;I. Goldstein;W. Peumans
缓激肽类似物诱导人皮肤肥大细胞释放组胺。
影响因子：
5.8
作者：
Lawrence,ID;Warner,JA;Cohan,VL;Lichtenstein,LM;Kagey-Sobotka,A;Vavrek,RJ;Stewart,JM;Proud,D
通讯作者：
Proud,D