NAD+ as a signaling molecule modulating metabolism.
NAD+ as a signaling molecule modulating metabolism.
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DOI:
10.1101/sqb.2012.76.010439
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发表时间:
2011
期刊:
影响因子:
--
通讯作者:
Auwerx J
中科院分区:
文献类型:
--
作者:
Cantó C;Auwerx J
The ability of NAD+ to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD+ levels in the control of whole body metabolic homeostasis. Bioavailability and compartmentalization of NAD+ have become highly relevant issues that we need to understand in order to elucidate how NAD+ acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.
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