NAD+ as a signaling molecule modulating metabolism.

NAD+ as a signaling molecule modulating metabolism.
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DOI:
10.1101/sqb.2012.76.010439
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发表时间:
2011
期刊:
Cold Spring Harbor symposia on quantitative biology
影响因子:
--
通讯作者:
Auwerx J
Auwerx J
中科院分区:
其他
文献类型:
--
作者:
Cantó C;Auwerx J

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NAD+作为代谢辅因子和许多酶(特别是沉默调节蛋白)的限速辅底物的能力,已经确定了NAD+水平在控制全身代谢稳态中的关键作用。NAD+的生物利用度和区室化已经成为我们需要了解的高度相关的问题,以阐明NAD+如何作为代谢环境的读出器和作为触发适当细胞适应的效应器。
The ability of NAD+ to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD+ levels in the control of whole body metabolic homeostasis. Bioavailability and compartmentalization of NAD+ have become highly relevant issues that we need to understand in order to elucidate how NAD+ acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.
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