Modeling 3-D deformation of outer hair cells and their production of the active force in the cochlea.
Modeling 3-D deformation of outer hair cells and their production of the active force in the cochlea.
复制标题
模拟外毛细胞的 3D 变形及其在耳蜗中产生的主动力。
DOI：
10.1007/s10237-002-0012-1
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Schmiedt,RA
中科院分区：
文献类型：
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作者：
Spector,AA;Ameen,M;Schmiedt,RA
我们分析了在生理条件下外毛细胞的变形及其产生的主动力。主动力有两个组成部分。一种是由耳蜗中Corti器官的负荷引起的应变引起的，并且取决于声信号的水平;另一种是与细胞膜的固有活性特性有关。我们证明了我们的方法，通过考虑，作为一个基本模型的外毛细胞的器官中的Corti，一个圆柱形的壳，充满了不可压缩的流体和位于两个平面之间，相对于彼此移动。这些平面代表基底膜和盖膜复合体。我们表明，变形状态的细胞具有3-D的性质，包括弯曲和扭曲的组件。这与通常测量主动力的实验条件不同。我们估计的主动力作为一个功能的相对位置的平面，角度的细胞的倾斜，和细胞的长度。
We analyze the deformation of the outer hair cell and its production of active force under physiological conditions. The active force has two components. One results from the strain caused by loading in the organ of Corti in the cochlea and depends on the level of the acoustic signal; the other is related to the intrinsic active properties of the cell membrane. We demonstrate our approach by considering, as a basic model of an outer hair cell in the organ of Corti, a cylindrical shell that is filled with an incompressible fluid and located between two planes that move relative to each other. These planes represent the basilar membrane and tectorial membrane complexes. We show that the deformed state of the cell has a 3-D nature, including bending and twisting components. This is different from the experimental conditions in which the active force is usually measured. We estimate the active force as a function of the relative position of the planes, angle of the cell's inclination, and the cell length.