AN ANALYSIS OF NONLINEAR DYNAMICS UNDERLYING NEURAL ACTIVITY RELATED TO AUDITORY INDUCTION IN THE RAT AUDITORY CORTEX
AN ANALYSIS OF NONLINEAR DYNAMICS UNDERLYING NEURAL ACTIVITY RELATED TO AUDITORY INDUCTION IN THE RAT AUDITORY CORTEX
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DOI：
10.1016/j.neuroscience.2015.12.060
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发表时间：
2016-03-24
期刊：
影响因子：
3.3
通讯作者：
Tateno, T.
中科院分区：
文献类型：
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作者：
Noto, M.;Nishikawa, J.;Tateno, T.
被寂静打断的声音被认为是不连续的。然而，当在静默期间插入高强度噪声时，丢失的声音可以被感知地恢复并且被听到为不间断的。这种错觉现象被称为听觉感应。最近的电生理研究表明，听觉感应与初级听觉皮层（A1）有关。虽然实验证据已经积累，在A1神经元的听觉诱导的神经机制知之甚少。为了阐明这一点，我们使用了实验和计算方法。首先，使用光学成像方法，我们的特点是人口的听觉皮层领域的声音反应，并确定了五个子领域的大鼠。接下来，我们研究了大鼠听觉皮层（AC）中与听觉诱导相关的神经群体活动，包括A1和其他几个AC子区域。我们的成像结果表明，由无声间隙中断的短纯音刺激引起的早期阶段性反应的第一个音和类似的或较小的反应的第二个音后的差距。相反，被宽带噪声（BN）中断的音调刺激，被认为是引起听觉诱导的，大大抑制或消除了对噪声后的音调的反应。此外，以音调频率为中心的陷波噪声中断的短纯音刺激，被认为是降低听觉诱导的强度，部分恢复了由BN引起的抑制的第二反应。为了从现象学上模拟A1中的神经群体活动，从而研究听觉诱导的机制，我们构建了一个从外周到AC的计算模型，包括一个非线性动力学系统。计算模型连续再现了上述实验结果。因此，我们的研究结果表明，一个非线性的，自激系统是一个关键因素，定性再现A1人口活动，并了解潜在的机制。(C)2016年IBRO。由Elsevier Ltd.出版。保留所有权利。
A sound interrupted by silence is perceived as discontinuous. However, when high-intensity noise is inserted during the silence, the missing sound may be perceptually restored and be heard as uninterrupted. This illusory phenomenon is called auditory induction. Recent electrophysiological studies have revealed that auditory induction is associated with the primary auditory cortex (A1). Although experimental evidence has been accumulating, the neural mechanisms underlying auditory induction in A1 neurons are poorly understood. To elucidate this, we used both experimental and computational approaches. First, using an optical imaging method, we characterized population responses across auditory cortical fields to sound and identified five subfields in rats. Next, we examined neural population activity related to auditory induction with high temporal and spatial resolution in the rat auditory cortex (AC), including the A1 and several other AC subfields. Our imaging results showed that tone-burst stimuli interrupted by a silent gap elicited early phasic responses to the first tone and similar or smaller responses to the second tone following the gap. In contrast, tone stimuli interrupted by broadband noise (BN), considered to cause auditory induction, considerably suppressed or eliminated responses to the tone following the noise. Additionally, tone-burst stimuli that were interrupted by notched noise centered at the tone frequency, which is considered to decrease the strength of auditory induction, partially restored the second responses from the suppression caused by BN. To phenomenologically mimic the neural population activity in the A1 and thus investigate the mechanisms underlying auditory induction, we constructed a computational model from the periphery through the AC, including a nonlinear dynamical system. The computational model successively reproduced some of the above-mentioned experimental results. Therefore, our results suggest that a nonlinear, self-exciting system is a key element for qualitatively reproducing A1 population activity and to understand the underlying mechanisms. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.