Correlations between Epstein-Barr virus antibody levels and risk factors for multiple sclerosis in healthy individuals
Correlations between Epstein-Barr virus antibody levels and risk factors for multiple sclerosis in healthy individuals
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DOI：
10.1177/1352458506071470
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发表时间：
2007-04-01
影响因子：
5.8
通讯作者：
Hjalgrim, H.
中科院分区：
文献类型：
--
作者：
Nielsen, T. R.;Pedersen, M.;Hjalgrim, H.
背景 女性、人类白细胞抗原 (HLA) DR2、吸烟和 Epstein-Barr 病毒 (EBV) 是多发性硬化症 (MS) 的既定危险因素。然而，它们之间可能的相互作用却很少被研究。目的 研究 EBV 抗体水平与一系列其他公认的 MS 危险因素之间可能存在的关联。设计、设置和研究人群 在丹麦进行的横断面研究，基于从丹麦人群中选出的 517 名健康个体。方法 我们使用线性回归测量了平均对数（抗 Epstein-Barr 病毒衣壳抗原 (VCA) 免疫球蛋白 G）的变化。结果 抗 Epstein-Barr VCA 免疫球蛋白 G 水平为与女性性别和HLA DR2呈正相关。此外，当前吸烟和累积烟草消费与EBV抗体水平呈正相关。结论 Epstein-Barr VCA抗体水平与非病毒性MS危险因素之间的关联支持EBV与MS病因学密切相关的观点。这些非病毒性 MS 危险因素可能通过 EBV 特异性免疫反应与 MS 风险相关。
Background Female gender, human leukocyte antigen (HLA) DR2, tobacco smoking and Epstein-Barr virus (EBV) are established risk factors for multiple sclerosis (MS). Their possible interaction however, has been sparsely studied.Objectives To investigate possible associations between EBV antibody levels and a range of other recognized MS risk factors.Design, setting and study population Cross-sectional study undertaken in Denmark based on 517 healthy individuals selected from the Danish population.Methods We measured change in mean log (anti-Epstein-Barr viral capsid antigen (VCA) immune globulin G) using linear regression.Results Anti-Epstein-Barr VCA immune globulin G levels were positively correlated with female gender and HLA DR2. Furthermore, current smoking and cumulative tobacco consumption were positively associated with EBV antibody levels.Conclusion The association between Epstein-Barr VCA antibody levels and non-viral MS risk factors support the view that EBV is critically involved in the etiology of MS. These non-viral MS risk factors may be linked with MS risk through EBV-specific immune responses.