ARTERIAL ADAPTATIONS TO ALTERED BLOOD-FLOW
ARTERIAL ADAPTATIONS TO ALTERED BLOOD-FLOW
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DOI：
10.1139/y91-147
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发表时间：
1991-07-01
影响因子：
2.1
通讯作者：
LANGILLE, BL
中科院分区：
文献类型：
--
作者：
BROWNLEE, RD;LANGILLE, BL
动脉重构是血管适应血流变化的重要机制，它与血流的发育、生理、病理和治疗有关。为了评估这种重塑，我们使用左至右颈动脉吻合术将成年家兔右侧颈总动脉的血流量增加60%。2个月后，这些血管没有代偿性增大。相比之下，在5- 6周龄断奶兔中进行的相同程序导致血管的加速生长：2个月后直径超过对照动脉的19%。颈外动脉结扎使兔颈总动脉血流量减少63%，颈总动脉内径缩小23%。这种适应恢复了施加在血管壁上的剪切应力，以控制水平。当用硝普钠、腺苷和毛喉素最大程度扩张血管时，直径减小并不逆转;然而，当重建正常血流时，直径在1周内恢复正常。因此，成人动脉对吻合术产生的血流量增加没有反应，但该手术确实逆转了对血流量减少的适应。相比之下，未成熟的动脉对血流的增加有反应，即使在没有预先进行血流调节的情况下。
Arterial remodeling in response to alter-ed blood flow is believed to be critical to vascular adaptations to developmental, physiological, pathological, and therapeutically induced changes in blood flow. To assess this remodeling, we used left-to-right carotid anastomosis to increase blood flow in the right common carotid arteries of adult rabbits by 60%. After 2 months, these vessels exhibited no compensatory enlargement. In contrast, the same procedure performed in 5- to 6-week-old weanling rabbits resulted in accelerated growth of the vessels: diameters exceeded those of control arteries by 19% after 2 months. Common carotid arteries in adult rabbits remodeled to produce a diameter reduced by 23% when blood flow was reduced by 63% by external carotid ligation. This adaptation restored shear stress exerted on the vessel wall to control levels. The reduced diameter was not reversed when the vessels were maximally dilated with nitroprusside, adenosine, and forskolin; however, normal diameters were restored within 1 week when normal blood flows were reestablished. Thus, the adult arteries did not respond to increased blood flow produced by the anastomosis, but this procedure did reverse adaptations to decreased flow. In contrast, immature arteries were responsive to this increase in blood flow, even in the absence of prior flow modulation.