Synthetic studies on (-)-lemonomycin: stereocontrolled construction of the 3,8-diazabicyclo[3.2.1] skeleton
Synthetic studies on (-)-lemonomycin: stereocontrolled construction of the 3,8-diazabicyclo[3.2.1] skeleton
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DOI：
10.1039/b415030a
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Fukuyama, T
中科院分区：
文献类型：
--
作者：
Rikimaru, K;Mori, K;Fukuyama, T
采用Ugi 4-CC反应、异氰化物8、13与烯丙基硅烷的交叉复分解反应和随后的分子内Hosomi Sakurai反应，立体选择性地合成了（-）-柠檬霉素（1）的五环关键中间体22。
Stereoselective synthesis of the pentacyclic key intermediate 22 for (-)-lemonomycin (1) has been accomplished using the Ugi 4-CC reaction with our novel isocyanide 8, a cross-metathesis of 13 and allylsilane and a subsequent intramolecular Hosomi Sakurai type reaction.