The neural basis of hallucinations and delusions
The neural basis of hallucinations and delusions
复制标题
DOI：
10.1016/j.crvi.2004.10.012
复制
发表时间：
2005-02-01
影响因子：
2
通讯作者：
Frith, C
中科院分区：
文献类型：
--
作者：
Frith, C
精神分裂症是一种生物学上的疾病，其特征是错误的感知（幻觉）和错误的信念（妄想）。这些精神异常的潜在生理原因仍然未知。越来越多的证据表明，一类症状，“制造的经验”，包括外星人控制和思想插入的妄想，与预测预期行为结果的机制异常有关（前向模型）。对于这些患者来说，主动运动感觉像被动运动。因此，这些患者感觉无法控制自己的行为。然而，与各种神经系统疾病，如与顶叶病变相关的神经系统疾病相比，表明这种异常体验不足以解释某种其他代理人控制的感觉是一个人的行为。初步证据表明，精神分裂症患者有一种夸大的能动感。这种夸张的能动性感，再加上无法控制的感觉，可以解释病人将自己的行为归因于另一个能动者的外星人控制妄想。我们对这种预测机制的神经基础知之甚少，这种机制让我们感觉自己在控制自己的动作。这种预测需要整合信息的预期运动产生的额叶皮层与感觉。大脑后部区域的处理过程。功能连接的措施表明，长距离之间的相互作用额叶和后部区域的精神分裂症患者异常减少。需要进一步研究，以探索远期模型机制中远程连接的确切参与。(C)2004年科学院。出版社：Elsevier SAS All rights reserved.
Schizophrenia is a biologically based disorder characterised by false perceptions (hallucinations) and false beliefs (delusions). The underlying physiological cause of these mental abnormalities remains unknown. There is increasing evidence that one class of symptom, the 'made experiences' including delusions of alien control and thought insertion, is associated with abnormalities in the mechanism that predicts the outcome of intended actions (the forward model). For these patients active movements feel like passive movements. As a result these patients do not feel in control of their actions. However, comparison with various neurological disorders, such as those associated with parietal lobe lesions, suggest that this abnormal experience is not sufficient to explain the feeling that some other agent is controlling is one's actions. Preliminary evidence suggests that patients with schizophrenia have an exaggerated sense of agency. In combination with the feeling of not being in control, this exaggerated sense of agency could explain delusions of alien control in which the patient attributes his own actions to another agent. Little is yet know about the neural basis of the predictive mechanisms that create the feeling that we are in control of our movements. Such prediction requires integration of information about intended movements generated in frontal cortex with sensory. processing in posterior regions of the brain. Measures of functional connectivity suggest that long-range interactions between frontal and posterior regions are abnormally reduced in patients with schizophrenia. Further research is needed to explore the precise involvement of long-range connections in the mechanisms of forward modelling. (C) 2004 Academie des sciences. Published by Elsevier SAS. All rights reserved.