HLA-A, B-ANTIGENS AND ALPHA-1-ANTITRYPSIN PHENOTYPES IN NODAL GENERALIZED OSTEO-ARTHRITIS AND EROSIVE OSTEO-ARTHRITIS
HLA-A, B-ANTIGENS AND ALPHA-1-ANTITRYPSIN PHENOTYPES IN NODAL GENERALIZED OSTEO-ARTHRITIS AND EROSIVE OSTEO-ARTHRITIS
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DOI：
10.1136/ard.48.6.470
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发表时间：
1989-06-01
影响因子：
27.4
通讯作者：
DOHERTY, M
中科院分区：
文献类型：
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作者：
PATTRICK, M;MANHIRE, A;DOHERTY, M
对90例确诊为结节性全面性骨关节炎(OA)的无关患者进行了人类白细胞抗原-A、B和α1-抗胰蛋白酶表型研究。与标准参考人群相比，HLAA1B8和MZα1-抗胰蛋白酶表型的频率独立增加(27%vs11.5%，相对危险度2.79和12%vs3.6%，相对危险度3.73)。这些关联与结节性全面性骨性关节炎的发展有关，而不是与手部骨性关节炎的综合放射学评分判断的严重程度有关。有10名患者有明显的软骨下骨侵蚀，并进一步被归类为侵蚀性骨性关节炎；这些患者有MSα1-抗胰蛋白酶表型的频率增加(30%对90%)，并有更高的放射学OA评分校正存在侵蚀的存在。这两个独立的遗传标记在结节性全身性骨性关节炎中的首次报道与骨关节炎过程中日益被认识的炎症成分有关。
HLA-A, B and .alpha.1-antitrypsin phenotypes were studied in 90 unrelated patients with established nodal generalised osteoarthritis (OA). Compared with standard reference populations, independently increased frequency of the HLA-A1B8 and MZ .alpha.1-antitrypsin phenotypes were observed (27% v 11.5%, relative risk 2.79, and 12% v 3.6%, relative risk 3.73 respectively). These associations related to development of nodal generalised OA rather than to severity as judged by the summated radiographic scores for hand OA. Ten patients had marked subcondral radiographic erosions and were further classified as erosive OA; these patients had an increased frequency of the MS .alpha.1-antitrypsin phenotype (30% v 90%) and higher radiographic OA scores corrected for presence of erosions. This first report of two independent genetic markers in nodal generalised OA is of interest in relation to the increasingly recognised inflammatory component of the osteoarthritis process.