Expression of NF-κB, CD68 and CD105 in carotid atherosclerotic plaque
Expression of NF-κB, CD68 and CD105 in carotid atherosclerotic plaque
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DOI：
10.3978/j.issn.2072-1439.2013.12.36
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发表时间：
2013-12-01
影响因子：
2.5
通讯作者：
Liu, Peng
中科院分区：
文献类型：
--
作者：
Ren, Shiyan;Fan, Xueqiang;Liu, Peng
颈动脉粥样硬化斑块易损性与脑血管事件相关。本研究旨在探讨炎症因子在颈动脉狭窄患者颈动脉粥样硬化斑块中的表达及其临床意义。43例颈动脉狭窄患者根据临床表现分为有症状组（n = 24）和无症状组（n = 19）。所有患者均行选择性标准颈动脉内膜剥脱术（CEA），手术切除颈动脉粥样硬化斑块，并进行病理学检查，检测NF-κ B（NF-kappa B）、CD 68和CD 105的表达。根据斑块中纤维帽的厚度和富脂核心的面积将斑块分为稳定斑块和不稳定斑块。有症状组不稳定斑块的比例明显高于无症状组（70.8%vs.63.2%，P = 0.026）。免疫组化染色结果显示不稳定斑块中NF-κ B、CD 68和CD 105的表达均高于稳定斑块（P < 0.001）。这些因子的高表达与颈动脉斑块不稳定性的关系有待进一步研究。
Atherosclerotic plaque vulnerability is associated with cerebrovascular events in patients with carotid atherosclerosis. The aim of this study was to investigate the expression of inflammatory factors in carotid artherosclerotic plaques in order to explore its clinical significance in patients with carotid stenosis. Forty three patients with carotid stenosis were divided into symptomatic group (n = 24) and asymptomatic group (n = 19) based on clinical manifestation. All patients were treated with selective standard carotid endarterectomy (CEA); the carotid atherosclerotic plaques were removed surgically and studied pathologically to investigate the expression of nuclear factor-kappa kappa (NF-kappa B), CD68 and CD105. The plaques were grouped into stable and unstable plaques based on thickness of the fibrous cap and the area of lipid-rich core in the plaques. The proportion of unstable plaques were significantly higher in symptomatic group than in asymptomatic group (70.8% vs. 63.2%, P = 0.026). Results of immunohistochemisty staining showed that the expression of NF-kappa B, CD68 and CD105 in unstable plaques was higher than stable plaques (P < 0.001). The association of the higher expression of these factors with instability of carotid plaque needs to be clarified in future study.