Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.
Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.
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DOI：
10.1084/jem.136.6.1430
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发表时间：
1972-12-01
影响因子：
15.3
通讯作者：
Klein, J
中科院分区：
文献类型：
--
作者：
Bach, F H;Widmer, M B;Bach, M L;Klein, J
混合白细胞培养（MLC）试验是同种移植物反应识别阶段的体外模型。在大多数情况下，MLC中的激活取决于主要组织相容性复合体（MHC）的差异。我们目前在小鼠中的研究表明，激活主要与MHC的遗传区域的差异有关，而不是那些控制血清学定义的（H-2）抗原的区域。尽管广泛免疫，这些差异不会导致细胞毒性或凝集抗体形成;我们将这些差异称为淋巴细胞定义（LD）差异。MLC中最强的刺激与Ir区域的差异有关。Ir产物可能是T细胞受体，并且它是可以在MLC中充当刺激剂的相同分子。其他的可能性进行了讨论。
The mixed leukocyte culture (MLC) test is an in vitro model of the recognition phase of the homograft response. For the most part, activation in MLC is dependent on differences of the major histocompatibility complex (MHC). Our present studies in the mouse suggest that activation is primarily associated with differences of genetic regions of the MHC other than those which control the serologically defined (H-2) antigens. These differences do not lead to cytotoxic or agglutinating antibody formation despite extensive immunization; we have called these differences lymphocyte-defined (LD) differences. The strongest stimulation in MLC is associated with differences of the Ir region. It is possible that the Ir product is the T cell receptor and that it is this same molecule which can act as the stimulatory agent in MLC. Other possibilities are discussed.