Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021.
Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021.
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DOI：
10.2807/1560-7917.es.2021.26.37.2100824
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发表时间：
2021-09
期刊：
影响因子：
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通讯作者：
Débarre F
中科院分区：
文献类型：
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作者：
Blanquart F;Abad C;Ambroise J;Bernard M;Cosentino G;Giannoli JM;Débarre F
我们比较了2021年6月14日至7月30日在法国社区检测的SARS-CoV-2阳性患者的聚合酶链式反应结果。在无症状个体中，完全接种的CQ值显著高于未完全接种的个体(效应值：1.7；95%CI：1-2.3；p <； 10−6)。在有症状的个体中，并控制症状出现后的时间，这种差异消失(p = 0.26)。感染Delta变异型的患者出现症状时的CQ值低于Alpha变异型(效应大小：−3.32；95%CI：−4.38至−2.25；p <； 10−6)。
We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1–2.3; p < 10−6). In symptomatic individuals and controlling for time since symptoms, the difference vanished (p = 0.26). Infections with the Delta variant had lower Cq values at symptom onset than with Alpha (effect size: −3.32; 95% CI: −4.38 to −2.25; p < 10−6).