Functional polymorphism in Z-DNA-forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects:: Association study and meta-analysis
Functional polymorphism in Z-DNA-forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects:: Association study and meta-analysis
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DOI：
10.1016/j.metabol.2004.12.006
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发表时间：
2005-05-01
影响因子：
9.8
通讯作者：
Ogihara, T
中科院分区：
文献类型：
--
作者：
Nishino, M;Ikegami, H;Ogihara, T
在总计244名日本受试者中研究了SLC 11 A1（溶质载体家族11成员1）（以前称为NRAMP 1（天然抗性相关巨噬细胞蛋白1））启动子区域中的Z-DNA形成重复序列的多态性与I型糖尿病的关联。在日本人中检测到三个等位基因。在糖尿病患者中，等位基因2的频率较低，等位基因3的频率较高，但不显着，比对照组。等位基因2与正常对照组相比有显著性差异（P
The association of the polymorphism of the Z-DNA-forming repeats in the promoter region of SLC11A1 (solute carrier family 11 member 1), formerly designated NRAMP1 (natural resistance associated macrophage protein 1), with type I diabetes was studied in a total of 244 Japanese subjects. Three alleles were detected in Japanese subjects. In diabetic patients, allele 2 was less frequent and allele 3 was more frequent, albeit not significantly, than in control subjects. Allele 2 was significantly (P