Comparison of pharmacovigilance algorithms in drug hypersensitivity reactions
Comparison of pharmacovigilance algorithms in drug hypersensitivity reactions
复制标题
药物超敏反应中药物警戒算法的比较
DOI：
10.1007/s00228-005-0962-1
复制
发表时间：
2005
影响因子：
2.9
通讯作者：
P. Demoly
中科院分区：
文献类型：
--
作者：
S. Benahmed;M. Picot;D. Hillaire;J. Blayac;P. Dujols;P. Demoly
BackgroundA firm diagnosis of drug hypersensitivity, because it may re-induce the reaction, is seldom confirmed. Causality assessment algorithms are therefore of interest.AimsThe objective of this work was to compare three algorithms in the diagnosis of drug hypersensitivity.MethodsEvaluation of 120 clinical histories of drug hypersensitivity was carried out: 60 involving β-lactams (50%) and 60 involving non-steroidal anti-inflammatory drugs (50%). Each of these groups of patients underwent a standardised allergy diagnosis, which included a detailed anamnesis, skin tests and, often, provocation tests under strict hospital surveillance. Unaware of the final allergy diagnosis, scores were established for all of the cases and compared using algorithms suggested by Begaud and coworkers [2, 20], Jones [13] and Naranjo et al. [21].ResultsAlthough the methods of Jones [13] and Naranjo et al. [21] were perfectly concordant (k=1), no concordance was noted using the Begaud and coworkers [2, 20] method.ConclusionsAll three algorithms are dissimilar regarding the diagnosis of drug hypersensitivity.
DOI：
10.1001/jama.274.1.35
发表时间：
1995-07
期刊：
JAMA
影响因子：
--
作者：
L. Leape;D. Bates;D. Cullen;J. Cooper;H. Demonaco;T. Gallivan;R. Hallisey;J. Ives;N. Laird;G. Laffel
通讯作者：
L. Leape;D. Bates;D. Cullen;J. Cooper;H. Demonaco;T. Gallivan;R. Hallisey;J. Ives;N. Laird;G. Laffel